caa a22 4500 445816554 CHVBK 20180317145230.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10815-010-9488-2 doi (NATIONALLICENCE)springer-10.1007/s10815-010-9488-2 Can anti-ovarian antibody testing be useful in an IVF-ET clinic? [Elektronische Daten] [Eusebio Pires, Firuza Parikh, Purvi Mande, Shonali Uttamchandani, Sujata Savkar, Vrinda Khole] Objective: To establish importance of anti-ovarian antibodies (AOA) testing in infertile women. Design: A clinical reproductive outcome comparative study between two groups of women undergoing IVF-ET. Group 1 consists of women tested positive for AOA, put on corticosteroid therapy, reverted to AOA negative and then taken up for IVF-ET. Group 2 were seronegative for AOA. Setting: Major urban infertility reference centre and National research institute. Patient(s): Five hundred seventy infertile women enrolled for IVF-ET. Intervention(s): AOA testing, corticosteroid therapy and IVF-ET/ICSI. Main outcome measure(s): Comparable clinical outcome and significance of AOA testing established. Results: AOA positive serum samples were sent periodically to re-investigate presence of AOA after corticosteroid therapy and women turned AOA negative were taken up for IVF-ET. Of the 70/138 women in group 1 who were treated with corticosteroids and turned seronegative for AOA, 22/70 were poor responders and needed donor oocyte-recipient cycles. Results demonstrated that fertilization and clinical pregnancy rates between both groups are comparable. Nevertheless, it is also observed that there is poor response to stimulation protocol, smaller number of oocytes retrieved and more spontaneous abortions in group 1 women. Hence not all outcomes following the treatment are comparable between the two groups. Usefulness of the test was established in two case studies. Conclusions: AOA testing could be included in the battery of tests investigating and treating infertility. Springer Science+Business Media, LLC, 2010 AOA, Infertility in women nationallicence IVF-ET success nationallicence IVF-ET treatment nationallicence Ovarian autoimmunity nationallicence Pires Eusebio Department of Gamete Immuno Biology, National Institute for Research in Reproductive Health (ICMR), J M Street, Parel, 400 012, Mumbai, India aut Parikh Firuza Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Pedder Road, 400 026, Mumbai, India aut Mande Purvi Department of Gamete Immuno Biology, National Institute for Research in Reproductive Health (ICMR), J M Street, Parel, 400 012, Mumbai, India aut Uttamchandani Shonali Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Pedder Road, 400 026, Mumbai, India aut Savkar Sujata Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Pedder Road, 400 026, Mumbai, India aut Khole Vrinda Department of Gamete Immuno Biology, National Institute for Research in Reproductive Health (ICMR), J M Street, Parel, 400 012, Mumbai, India aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/1(2011-01-01), 55-64 1058-0468 28:1<55 2011 28 10815 https://doi.org/10.1007/s10815-010-9488-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9488-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pires Eusebio Department of Gamete Immuno Biology, National Institute for Research in Reproductive Health (ICMR), J M Street, Parel, 400 012, Mumbai, India aut NATIONALLICENCE 700 1- Parikh Firuza Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Pedder Road, 400 026, Mumbai, India aut NATIONALLICENCE 700 1- Mande Purvi Department of Gamete Immuno Biology, National Institute for Research in Reproductive Health (ICMR), J M Street, Parel, 400 012, Mumbai, India aut NATIONALLICENCE 700 1- Uttamchandani Shonali Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Pedder Road, 400 026, Mumbai, India aut NATIONALLICENCE 700 1- Savkar Sujata Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Pedder Road, 400 026, Mumbai, India aut NATIONALLICENCE 700 1- Khole Vrinda Department of Gamete Immuno Biology, National Institute for Research in Reproductive Health (ICMR), J M Street, Parel, 400 012, Mumbai, India aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/1(2011-01-01), 55-64 1058-0468 28:1<55 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer