caa a22 4500 445816600 CHVBK 20180317145230.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10815-011-9589-6 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9589-6 Anti-mullerian hormone as a predictive marker for the selection of women for oocyte in vitro maturation treatment [Elektronische Daten] [Rubens Fadini, Ruggero Comi, Mario Mignini Renzini, Giovanni Coticchio, Marilena Crippa, Elena De Ponti, Mariabeatrice Dal Canto] Purpose: In oocyte in-vitro maturation (IVM) treatments, the chances to achieve a pregnancy are critically dependent on the retrieval of a suitable number of oocytes. In this study, we assessed the ability of circulating levels of anti-mullerian hormone (AMH) to identify normo-ovulatory women suitable for IVM treatment on the basis of the number of retrieved oocytes. Method: Serum AMH was quantified in normo-ovulatory women younger than 39years undergoing IVM treatment. After immature oocyte retrieval and IVM, maximum 3 mature oocytes were used for treatment and all resulting embryos were transferred, as established by law. From 177 cycles, 991 oocytes were recovered. Following IVM, 484 mature oocytes were obtained (50.1%). Results: The overall pregnancy rate per embryo transfer was 16.6% (25/151) and the implantation rate was 10.9% (30/278). Linear regression and receiver operating characteristic (ROC) analyses were applied to identify independent variables and quantify a cut-off AMH value able to identify patients suitable for IVM treatment. An AMH value of 1.28ng/ml was identified as a threshold for the prediction of the retrieval of at least 5 oocytes, with a sensitivity of 93.4% and a specificity of 33.8%. Positive and negative predictive values were 67.6% and 75.0%, respectively. Conclusions: AMH can be adopted to identify women candidate for an IVM treatment from whom a suitable number of oocytes may be retrieved. This is of crucial significance during a non-stimulated cycle, in order to prevent an insufficient oocyte collection and rescue the treatment by implementing a conventional controlled ovarian stimulation. Springer Science+Business Media, LLC, 2011 In vitro maturation nationallicence Oocytes nationallicence Anti-mullerian hormone nationallicence Female age nationallicence Pregnancy rate nationallicence Fadini Rubens BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut Comi Ruggero BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut Mignini Renzini Mario BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut Coticchio Giovanni BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut Crippa Marilena BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut De Ponti Elena Department of Medical Physics, San Gerardo Hospital, Monza, Italy aut Dal Canto Mariabeatrice BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/6(2011-06-01), 501-508 1058-0468 28:6<501 2011 28 10815 https://doi.org/10.1007/s10815-011-9589-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9589-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fadini Rubens BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut NATIONALLICENCE 700 1- Comi Ruggero BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut NATIONALLICENCE 700 1- Mignini Renzini Mario BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut NATIONALLICENCE 700 1- Coticchio Giovanni BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut NATIONALLICENCE 700 1- Crippa Marilena BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut NATIONALLICENCE 700 1- De Ponti Elena Department of Medical Physics, San Gerardo Hospital, Monza, Italy aut NATIONALLICENCE 700 1- Dal Canto Mariabeatrice BIOGENESI, Reproductive Medicine Centre, Istituti Clinici Zucchi, Via Zucchi 24, 20052, Monza, Italy aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/6(2011-06-01), 501-508 1058-0468 28:6<501 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer