caa a22 4500 445816643 CHVBK 20180317145230.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10815-011-9592-y doi (NATIONALLICENCE)springer-10.1007/s10815-011-9592-y The impact of obesity on egg quality [Elektronische Daten] [Scott Purcell, Kelle Moley] Obesity in women is a concern in many countries. This causes numerous health issues; however, this review focuses on the impact of obesity on women's reproduction, and in particular the oocyte. Data from infertility clinics and experimental animal models that address the effects of obesity are presented. Bidirectional communication and metabolic support from the surrounding cumulus cells are critical for oocyte development, and the impact of obesity on these cells is also addressed. Both oocyte maturation and metabolism are impaired due to obesity, negatively impacting further development. In addition to reproductive hormones, obesity induced elevations in insulin, glucose, or free fatty acids, and changes in adipokines appear to impact the developmental competence of the oocyte. The data indicate that any one of these hormones or metabolites can impair oocyte developmental competence in vivo, and the combination of all of these factors and their interactions are the subject of ongoing investigations. Springer Science+Business Media, LLC, 2011 Oocyte nationallicence Cumulus cell nationallicence Obesity nationallicence Metabolism nationallicence Infertility nationallicence Purcell Scott Department of Obstetrics and Gynecology, Washington University in St. Louis, 660 South Euclid Ave., 63110, St. Louis, MO, USA aut Moley Kelle Department of Obstetrics and Gynecology, Washington University in St. Louis, 660 South Euclid Ave., 63110, St. Louis, MO, USA aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/6(2011-06-01), 517-524 1058-0468 28:6<517 2011 28 10815 https://doi.org/10.1007/s10815-011-9592-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9592-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Purcell Scott Department of Obstetrics and Gynecology, Washington University in St. Louis, 660 South Euclid Ave., 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Moley Kelle Department of Obstetrics and Gynecology, Washington University in St. Louis, 660 South Euclid Ave., 63110, St. Louis, MO, USA aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/6(2011-06-01), 517-524 1058-0468 28:6<517 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer