caa a22 4500 445816767 CHVBK 20180317145230.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10815-011-9595-8 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9595-8 Estradiol supplementation during the luteal phase in poor responder patients undergoing in vitro fertilization: a randomized clinical trial [Elektronische Daten] [Marzieh Aghahosseini, Ashraf Aleyassin, Sepideh Khodaverdi, Fatemeh Esfahani, Robabeh Mohammadbeigi, Shohreh Movahedi, Ali Kord Valeshabad, Atossa Mahdavi, Parvin Fallahi, Parisa Shabani, Zahra Rezaeeian, Maryam Khodaverdi] Purpose: This study was designed to evaluate the effects of adding Estradiol (E2) supplementation to progesterone (P) on improvement of pregnancy outcomes in poor responder patients who underwent in vitro fertilization (IVF). Methods: In a prospective randomized clinical trial, 118 poor responder patients, older than 38years without contraindications of estradiol consumption from Infertility clinic of a university hospital were randomly divided (by computerized software) into two groups. Control group (59 patients) received only P and intervention group (59 patients) received P and E2 (4mg/d). Supplementation was done with 4mg E2 in the luteal phase. Fertilization rate, implantation rate, biochemical and clinical pregnancy rates, abortion rate, ongoing pregnancy, multiple pregnancy and ectopic pregnancy rates were documented for those who completed the study protocol in each group (per protocol analysis) and compared between groups. Result: Fifty five patients in control group and 53 patients in intervention group successfully completed the study protocol. Treatment outcomes were not significantly different between two groups. Conclusion: For poor responder women who underwent IVF, addition of E2 to P supplementation could not significantly improve pregnancy outcomes. Springer Science+Business Media, LLC, 2011 E2 supplementation nationallicence Luteal phase support nationallicence Implantation rate nationallicence Poor responder patients nationallicence IVF nationallicence Aghahosseini Marzieh Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut Aleyassin Ashraf Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut Khodaverdi Sepideh Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut Esfahani Fatemeh Research Development Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran aut Mohammadbeigi Robabeh Kurdistan University of Medical Sciences, Sanandaj, Iran aut Movahedi Shohreh Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut Kord Valeshabad Ali Students's Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), North Karegar Street, 1439957181, Tehran, Iran aut Mahdavi Atossa Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut Fallahi Parvin Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut Shabani Parisa Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut Rezaeeian Zahra Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut Khodaverdi Maryam Research Development Center, Zanjan University of Medical Sciences, Zanjan, Iran aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/9(2011-09-01), 785-790 1058-0468 28:9<785 2011 28 10815 https://doi.org/10.1007/s10815-011-9595-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9595-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aghahosseini Marzieh Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut NATIONALLICENCE 700 1- Aleyassin Ashraf Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut NATIONALLICENCE 700 1- Khodaverdi Sepideh Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut NATIONALLICENCE 700 1- Esfahani Fatemeh Research Development Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Mohammadbeigi Robabeh Kurdistan University of Medical Sciences, Sanandaj, Iran aut NATIONALLICENCE 700 1- Movahedi Shohreh Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut NATIONALLICENCE 700 1- Kord Valeshabad Ali Students's Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), North Karegar Street, 1439957181, Tehran, Iran aut NATIONALLICENCE 700 1- Mahdavi Atossa Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut NATIONALLICENCE 700 1- Fallahi Parvin Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut NATIONALLICENCE 700 1- Shabani Parisa Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut NATIONALLICENCE 700 1- Rezaeeian Zahra Department of Infertility, Zanjan University of Medical Sciences, North Karegar Street, 1411713135, Zanjan, Iran aut NATIONALLICENCE 700 1- Khodaverdi Maryam Research Development Center, Zanjan University of Medical Sciences, Zanjan, Iran aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/9(2011-09-01), 785-790 1058-0468 28:9<785 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer