caa a22 4500 445816791 CHVBK 20180317145231.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10815-011-9607-8 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9607-8 Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome [Elektronische Daten] [Pervin Vural, Müge Kanmaz-Özer, Semra Doğru-Abbasoğlu, Ali Gedikbaşı, Esra Çil, Berrin Karadağ, Müjdat Uysal] Purpose: This study examined the possible association of G241R and K469E single nucleotide polymorphisms (SNPs) of ICAM-1 gene with the occurrence and clinical/biochemical characteristics of polycystic ovary syndrome (PCOS). Methods: G241R and K469E SNPs in DNA from peripheral blood leukocytes of 169 PCOS and 259 healthy control women were investigated by real-time PCR combined with melting curve analysis using fluorescence-labeled hybridization probes. Results: We did not find significant differences in the distributions of G241R and K469E polymorphisms, nor in the haplotype frequencies between PCOS and control women. None of the studied polymorphisms were found to affect insulin resistance indices significantly. Conclusions: These preliminary results suggest that the 241 and 469 SNPs of ICAM-1 gene may not be risk factors for PCOS. Further studies with a larger cohort, analyzing other ICAM-1 polymorphisms are necessary to support our observations before any statement can be made about the relationship between PCOS and ICAM-1 polymorphisms. Springer Science+Business Media, LLC, 2011 Polycystic ovary syndrome nationallicence Intercellular adhesion molecule-1 nationallicence Polymorphism nationallicence Insulin resistance nationallicence Vural Pervin Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, 34093, Istanbul, Turkey aut Kanmaz-Özer Müge Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, 34093, Istanbul, Turkey aut Doğru-Abbasoğlu Semra Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, 34093, Istanbul, Turkey aut Gedikbaşı Ali Maternal and Fetal Unit, Department of Obstetrics and Gynecology, Istanbul Bakirkoy Women and Children Hospital, Istanbul, Turkey aut Çil Esra Department of Internal Medicine, Division of Endocrinology, Şişli Etfal Research and Training Hospital, Şişli, Istanbul, Turkey aut Karadağ Berrin Department of Internal Medicine, Division of Endocrinology, Şişli Etfal Research and Training Hospital, Şişli, Istanbul, Turkey aut Uysal Müjdat Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, 34093, Istanbul, Turkey aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/9(2011-09-01), 869-875 1058-0468 28:9<869 2011 28 10815 https://doi.org/10.1007/s10815-011-9607-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9607-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vural Pervin Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, 34093, Istanbul, Turkey aut NATIONALLICENCE 700 1- Kanmaz-Özer Müge Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, 34093, Istanbul, Turkey aut NATIONALLICENCE 700 1- Doğru-Abbasoğlu Semra Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, 34093, Istanbul, Turkey aut NATIONALLICENCE 700 1- Gedikbaşı Ali Maternal and Fetal Unit, Department of Obstetrics and Gynecology, Istanbul Bakirkoy Women and Children Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Çil Esra Department of Internal Medicine, Division of Endocrinology, Şişli Etfal Research and Training Hospital, Şişli, Istanbul, Turkey aut NATIONALLICENCE 700 1- Karadağ Berrin Department of Internal Medicine, Division of Endocrinology, Şişli Etfal Research and Training Hospital, Şişli, Istanbul, Turkey aut NATIONALLICENCE 700 1- Uysal Müjdat Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, 34093, Istanbul, Turkey aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/9(2011-09-01), 869-875 1058-0468 28:9<869 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer