caa a22 4500 445816813 CHVBK 20180317145231.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10815-011-9588-7 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9588-7 The contribution of mitochondrial function to reproductive aging [Elektronische Daten] [Yaakov Bentov, Tetyana Yavorska, Navid Esfandiari, Andrea Jurisicova, Robert Casper] Purpose: The number of women attempting to conceive between the ages of 36 and 44 has increased significantly in the last decade. While it is well established that women's reproductive success dramatically declines with age, the underlying physiological changes responsible for this phenomenon are not well understood. With assisted reproductive technologies, it is clear that oocyte quality is a likely cause since women over 40 undergoing in vitro fertilization (IVF) with oocytes donated by younger women have success rates comparable to young patients. Apart from oocyte donation, there is no known intervention to improve the pregnancy outcome of older patients. The aim of this paper was the review the relevant data on the potential role of mitochondria in reproductive aging. Method: Review of current literature on the subject. Results: We present the current evidence that associate mitochondrial dysfunction with age related decrease in female reproductive outcome. Conclusions: The aging process is complex, driven by a multitude of factors thought to modulate cellular and organism life span. Although the factors responsible for diminished oocyte quality remain to be elucidated, the present review focuses on the potential role of impaired mitochondrial function. Springer Science+Business Media, LLC, 2011 Reproductive aging nationallicence Oocyte nationallicence Embryo nationallicence Aneuploidy nationallicence Mitochondria nationallicence Mitochondrial DNA nationallicence Bentov Yaakov Toronto Centre for Advanced Reproductive Technology, University of Toronto, Toronto, ON, Canada aut Yavorska Tetyana Department of Physiology, University of Toronto, Toronto, ON, Canada aut Esfandiari Navid Toronto Centre for Advanced Reproductive Technology, University of Toronto, Toronto, ON, Canada aut Jurisicova Andrea Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada aut Casper Robert Toronto Centre for Advanced Reproductive Technology, University of Toronto, Toronto, ON, Canada aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/9(2011-09-01), 773-783 1058-0468 28:9<773 2011 28 10815 https://doi.org/10.1007/s10815-011-9588-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9588-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bentov Yaakov Toronto Centre for Advanced Reproductive Technology, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Yavorska Tetyana Department of Physiology, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Esfandiari Navid Toronto Centre for Advanced Reproductive Technology, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Jurisicova Andrea Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Casper Robert Toronto Centre for Advanced Reproductive Technology, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/9(2011-09-01), 773-783 1058-0468 28:9<773 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer