caa a22 4500 445816856 CHVBK 20180317145231.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10815-011-9567-z doi (NATIONALLICENCE)springer-10.1007/s10815-011-9567-z Anti-Mullerian hormone and antral follicle count as predictors for embryo/oocyte cryopreservation cycle outcomes in breast cancer patients stimulated with letrozole and follicle stimulating hormone [Elektronische Daten] [Sanghoon Lee, Sinan Ozkavukcu, Elke Heytens, Fred Moy, Rose Alappat, Kutluk Oktay] Purpose: To predict embryo/oocyte cryopreservation cycle (ECC) outcomes in breast cancer patients stimulated with letrozole and follicle stimulating hormone for fertility preservation based on observed anti-mullerian hormone (AMH) levels and antral follicle counts (AFC). Methods: The correlation between AMH and AFC and ECC outcomes were analyzed retrospectively on forty one women with breast cancer before adjuvant treatment. Results: AMH and AFC had a stronger correlation with the total number of oocytes and the number of mature oocytes than age, FSH, and inhibin B. Subjects were evaluated by the number of mature oocytes retrieved to create cutoff points of AMH level, which identified 1.2ng/mL as a potential value. Seven of 18 patients with AMH levels ≤1.2ng/mL had low response versus none of 23 with >1.2ng/mL, (p = 0.001). Conclusions: AMH is the most reliable serum marker of ECC outcomes, together with AFC as a biophysical marker, in breast cancer patients. Low response is highly likely when the AMH level is ≤1.2ng/mL. Springer Science+Business Media, LLC, 2011 Anti-Mullerian hormone (AMH) nationallicence Letrozole nationallicence Breast cancer nationallicence Fertility preservation nationallicence Cryopreservation nationallicence Lee Sanghoon Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, 10595, Valhalla, NY, USA aut Ozkavukcu Sinan Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, 10595, Valhalla, NY, USA aut Heytens Elke Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, 10595, Valhalla, NY, USA aut Moy Fred Biometrics, Data Management and PK/PD Unit, Graduate School of Basic Medical Sciences, Department of Pathology, New York Medical College, 10595, Valhalla, NY, USA aut Alappat Rose Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, 10595, Valhalla, NY, USA aut Oktay Kutluk Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, 10595, Valhalla, NY, USA aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/7(2011-07-01), 651-656 1058-0468 28:7<651 2011 28 10815 https://doi.org/10.1007/s10815-011-9567-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9567-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Sanghoon Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, 10595, Valhalla, NY, USA aut NATIONALLICENCE 700 1- Ozkavukcu Sinan Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, 10595, Valhalla, NY, USA aut NATIONALLICENCE 700 1- Heytens Elke Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, 10595, Valhalla, NY, USA aut NATIONALLICENCE 700 1- Moy Fred Biometrics, Data Management and PK/PD Unit, Graduate School of Basic Medical Sciences, Department of Pathology, New York Medical College, 10595, Valhalla, NY, USA aut NATIONALLICENCE 700 1- Alappat Rose Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, 10595, Valhalla, NY, USA aut NATIONALLICENCE 700 1- Oktay Kutluk Institute for Fertility Preservation and Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, 10595, Valhalla, NY, USA aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/7(2011-07-01), 651-656 1058-0468 28:7<651 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer