caa a22 4500 445816864 CHVBK 20180317145231.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10815-011-9553-5 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9553-5 Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdown [Elektronische Daten] [Agnieszka Lechowska, Szczepan Bilinski, Youngsok Choi, Yonghyun Shin, Malgorzata Kloc, Aleksandar Rajkovic] Purpose: To understand the mechanism of premature ovarian failure (POF). Methods: The ultrastructural (electron microscopy) analysis of primordial ovarian follicles in Nobox deficient mice. Results: We studied, for the first time, the fate of oogonia in embryonic (prenatal) mouse ovaries and showed that the abolishment of the transition from germ cell cysts to primordial follicles in the ovaries of Nobox deficient mice is caused by defects in germ cell cyst breakdown, leading to the formation of syncytial follicles instead of primordial follicles. Conclusions: These results indicate that POF syndrome in Nobox deficient mice results from the faulty signaling between somatic and germ line components during embryonic development. In addition, the extremely unusual and abnormal presence of adherens junctions between unseparated oocytes within syncytial follicles indicates that faulty communication between somatic and germ cells is involved in, or leads to, abnormalities in the cell adhesion program. Springer Science+Business Media, LLC, 2011 Premature ovarian failure nationallicence Nobox nationallicence Homeobox nationallicence Ovary nationallicence Germ cells nationallicence Lechowska Agnieszka Institute of Zoology, Jagiellonian University, Krakow, Poland aut Bilinski Szczepan Institute of Zoology, Jagiellonian University, Krakow, Poland aut Choi Youngsok Department of Biomedical Sciences, CHA University, Seoul, The Republic of Korea aut Shin Yonghyun Magee Women's Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, 15213, Pittsburgh, PA, USA aut Kloc Malgorzata Department of Surgery, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX, USA aut Rajkovic Aleksandar Magee Women's Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, 15213, Pittsburgh, PA, USA aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/7(2011-07-01), 583-589 1058-0468 28:7<583 2011 28 10815 https://doi.org/10.1007/s10815-011-9553-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9553-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lechowska Agnieszka Institute of Zoology, Jagiellonian University, Krakow, Poland aut NATIONALLICENCE 700 1- Bilinski Szczepan Institute of Zoology, Jagiellonian University, Krakow, Poland aut NATIONALLICENCE 700 1- Choi Youngsok Department of Biomedical Sciences, CHA University, Seoul, The Republic of Korea aut NATIONALLICENCE 700 1- Shin Yonghyun Magee Women's Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Kloc Malgorzata Department of Surgery, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX, USA aut NATIONALLICENCE 700 1- Rajkovic Aleksandar Magee Women's Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/7(2011-07-01), 583-589 1058-0468 28:7<583 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer