caa a22 4500 445816961 CHVBK 20180317145231.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10815-011-9564-2 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9564-2 The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study [Elektronische Daten] [Sedigheh Ghandi, Abbas Aflatoonian, Nasim Tabibnejad, Mohammad Moghaddam] Purpose: Comparing the effects of metformin or orlistat on hormone, lipid profile and ovulation status in obese women with polycystic ovary syndrome. Methods: A total of 80 women were prospectively recruited to receive either metformin (n = 40) or orlistat (n = 40). Weight, BMI, waist, serum LH, total serum testosterone and lipid profile were assessed at baseline and after 3months. The subjects' ovulatory status was assessed after 3months. Results: There was no significant difference in ovulation between the two treatment groups (30% vs 15%). Treatment with either drug showed a significant decline in body weight, BMI (Body Mass Index), and waist circumference, but the degree of decline in both groups was the same. Patients who were treated with orlistat, showed a significant reduction in total testosterone and serum lipid. Women in metformin group showed a significant reduction in serum LH. Conclusions: Both metformin and orlistat showed a similar effect on weight loss and ovulation rates. Springer Science+Business Media, LLC, 2011 Metformin nationallicence Orlistat nationallicence PCOS nationallicence Weight loss nationallicence Waist circumference nationallicence Ghandi Sedigheh Department of Obstetrics & Gynecology, Sabzevar University of Medical Sciences, Sabzevar, Iran aut Aflatoonian Abbas Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran aut Tabibnejad Nasim Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran aut Moghaddam Mohammad Department of Obstetrics & Gynecology, Sabzevar University of Medical Sciences, Sabzevar, Iran aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/7(2011-07-01), 591-596 1058-0468 28:7<591 2011 28 10815 https://doi.org/10.1007/s10815-011-9564-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9564-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ghandi Sedigheh Department of Obstetrics & Gynecology, Sabzevar University of Medical Sciences, Sabzevar, Iran aut NATIONALLICENCE 700 1- Aflatoonian Abbas Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran aut NATIONALLICENCE 700 1- Tabibnejad Nasim Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran aut NATIONALLICENCE 700 1- Moghaddam Mohammad Department of Obstetrics & Gynecology, Sabzevar University of Medical Sciences, Sabzevar, Iran aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/7(2011-07-01), 591-596 1058-0468 28:7<591 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer