caa a22 4500 44581697X CHVBK 20180317145231.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10815-011-9551-7 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9551-7 Frozen-thawed embryo transfer cycles: clinical outcomes of single and double blastocyst transfers [Elektronische Daten] [Inna Berin, Sarah McLellan, Eric Macklin, Thomas Toth, Diane Wright] Purpose: To evaluate clinical outcomes of frozen-thawed embryo transfer cycles when one or two blastocysts are transferred. Methods: Retrospective chart review Results: Two hundred forty-three frozen blastocyst transfer (FBT) cycles were analyzed. Clinical pregnancy rate (50.4% vs. 34.7%), live birth rate (45.8% vs. 30.6%), and twin live birth rate (19.3% vs. 0) were significantly higher in the double versus single FBT group, respectively (p < 0.05). Prior fresh cycle success with same-cohort embryos did not predict outcome of FBT cycle. When the fresh cycle was unsuccessful, there still was a significant increase in twinning when two frozen-thawed blastocysts were transferred. Conclusions: Transferring two blastocysts during an FBT cycle resulted in higher live birth and twin live birth rates. Single FBT provided acceptable pregnancy rates for couples seeking to avoid a multiple pregnancy or for those having a single blastocyst stored. Interestingly, the outcome of fresh cycle with same-cohort embryos did not influence the outcome of frozen-thawed cycle. Springer Science+Business Media, LLC, 2011 Frozen blastocyst transfer nationallicence Frozen cycle outcome nationallicence IVF nationallicence Multiple pregnancy nationallicence Number of embryos to transfer nationallicence Berin Inna Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 10A, 02114, Boston, MA, USA aut McLellan Sarah Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 10A, 02114, Boston, MA, USA aut Macklin Eric Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA aut Toth Thomas Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 10A, 02114, Boston, MA, USA aut Wright Diane Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 10A, 02114, Boston, MA, USA aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/7(2011-07-01), 575-581 1058-0468 28:7<575 2011 28 10815 https://doi.org/10.1007/s10815-011-9551-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9551-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berin Inna Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 10A, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- McLellan Sarah Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 10A, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Macklin Eric Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Toth Thomas Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 10A, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Wright Diane Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 10A, 02114, Boston, MA, USA aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/7(2011-07-01), 575-581 1058-0468 28:7<575 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer