caa a22 4500 445817100 CHVBK 20180317145232.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10815-011-9652-3 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9652-3 Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation [Elektronische Daten] [E. Dickerson, T. Sathyapalan, R. Knight, S. Maguiness, S. Killick, J. Robinson, S. Atkin] Purpose: There is increasing concern that environmental chemicals have a direct effect on fertility. Heavy metals such as mercury have been shown to affect various organ systems in humans including nervous system and skin, however they could also act as endocrine disrupting chemicals adversely affecting fertility. Metals such as zinc and selenium are essential micronutrients with diverse functions that may be important for reproductive outcomes. We measured mercury, zinc and selenium levels in the hair, a reliable reflection of long term environmental exposure and dietary status, to correlate with the outcome of ovarian hyperstimulation for in vitro fertilisation (IVF) treatment. Methods: We analysed the hair of 30 subfertile women for mercury, zinc and selenium using inductively coupled mass spectrometry. Each woman underwent one cycle of IVF treatment. Correlation between the levels of these trace metals and treatment outcomes was investigated. Results: Thirty women were recruited with mean (±SD) age of 32.7(4.4) years and BMI of 25.4(5.0)kg/m2. Hair mercury concentration showed a negative correlation with oocyte yield (p < 0.05,βcoefficient 0.38) and follicle number (p = 0.03,β coefficient0.19) after ovarian stimulation. Zinc and selenium levels in hair correlated positively with oocyte yield after ovarian stimulation (p < 0.05,β coefficient0.15) and (p = 0.03,β coefficient0.21) respectively. Selenium levels in hair correlated significantly with follicle number following stimulation (p = 0.04, βcoefficient0.22). There was no correlation between mercury, zinc and selenium in hair and their corresponding serum levels. Conclusion: These data suggest that mercury had a deleterious effect whilst there was a positive effect for zinc and selenium in the ovarian response to gonadotrophin therapy for IVF. Hair analysis offers a novel method of investigating the impact of long-term exposure to endocrine disruptors and nutritional status on reproductive outcomes. Springer Science+Business Media, LLC, 2011 IVF nationallicence Heavy metals nationallicence Endocrine disruptors nationallicence Dickerson E. Hull IVF Unit, Hull Women and Children's Hospital, Kingston-upon-Hull, UK aut Sathyapalan T. Hull York Medical School, University of Hull, Kingston-upon-Hull, UK aut Knight R. Department of Chemistry, University of Hull, Kingston-upon-Hull, UK aut Maguiness S. Hull IVF Unit, Hull Women and Children's Hospital, Kingston-upon-Hull, UK aut Killick S. Hull IVF Unit, Hull Women and Children's Hospital, Kingston-upon-Hull, UK aut Robinson J. Hull IVF Unit, Hull Women and Children's Hospital, Kingston-upon-Hull, UK aut Atkin S. Hull York Medical School, University of Hull, Kingston-upon-Hull, UK aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/12(2011-12-01), 1223-1228 1058-0468 28:12<1223 2011 28 10815 https://doi.org/10.1007/s10815-011-9652-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9652-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dickerson E. Hull IVF Unit, Hull Women and Children's Hospital, Kingston-upon-Hull, UK aut NATIONALLICENCE 700 1- Sathyapalan T. Hull York Medical School, University of Hull, Kingston-upon-Hull, UK aut NATIONALLICENCE 700 1- Knight R. Department of Chemistry, University of Hull, Kingston-upon-Hull, UK aut NATIONALLICENCE 700 1- Maguiness S. Hull IVF Unit, Hull Women and Children's Hospital, Kingston-upon-Hull, UK aut NATIONALLICENCE 700 1- Killick S. Hull IVF Unit, Hull Women and Children's Hospital, Kingston-upon-Hull, UK aut NATIONALLICENCE 700 1- Robinson J. Hull IVF Unit, Hull Women and Children's Hospital, Kingston-upon-Hull, UK aut NATIONALLICENCE 700 1- Atkin S. Hull York Medical School, University of Hull, Kingston-upon-Hull, UK aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/12(2011-12-01), 1223-1228 1058-0468 28:12<1223 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer