caa a22 4500 445817127 CHVBK 20180317145232.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10815-011-9627-4 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9627-4 Serum anti-Müllerian hormone and antral follicle count as predictive markers of OHSS in ART cycles [Elektronische Daten] [Pelin Ocal, Sezai Sahmay, Meral Cetin, Tulay Irez, Onur Guralp, Ismail Cepni] Objective: To evaluate predictive role of day-3 serum anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) in ovarian hyperstimulation syndrome (OHSS) in patients undergoing IVF/ICSI cycles. Materials and methods: Forty-one women with moderate/severe OHSS and 41 age matched women without OHSS were compared to evaluate the predictive value of certain risk factors for OHSS. AFC, and E2, FSH, LH, AMH, inhibin-B levels measured on day3 of the menstrual cycle before controlled ovarian hyperstimulation. Results: Mean FSH was significantly lower (p < 0.0001); and mean LH, AFC and AMH were significantly higher in women with OHSS compared to women without OHSS (p = 0.049, p < 0.0001 and p < 0.0001, respectively). There was no significant difference in inhibin B (p = 0.112) and estradiol (p = 0.706) between the groups. The ROC area under curve (AUC) for AMH presented the largest AUC among the listed risk factors. AMH (AUC = 0.87) and AFC (AUC = 0.74) had moderate accuracy for predicting OHSS while Inhibin B (AUC = 0.58) and LH (AUC = 0.61) had low accuracy. The cut-off value for AMH 3.3ng/mL provided the highest sensitivity (90%) and specificity (71%) for predicting OHSS. It's positive (PPV) and negative predictive values (NPV) were 61% and 94%, respectively. The cut-off value for AFC was 8 with 78% sensitivity, 65% specificity, 52% PPV and 86% NPV. Conclusion: Measurement of basal serum AMH and AFC can be used to determine the women with high risk for OHSS. Springer Science+Business Media, LLC, 2011 Antimullerian hormone nationallicence Ovarian hyperstimulation syndrome nationallicence Antral follicle count nationallicence Ocal Pelin Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Fatih, Turkey aut Sahmay Sezai Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Fatih, Turkey aut Cetin Meral Department of Obstetrics and Gynecology, Cumhuriyet University Medical School, Sivas, Turkey aut Irez Tulay Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Fatih, Turkey aut Guralp Onur Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Fatih, Turkey aut Cepni Ismail Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Fatih, Turkey aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/12(2011-12-01), 1197-1203 1058-0468 28:12<1197 2011 28 10815 https://doi.org/10.1007/s10815-011-9627-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9627-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ocal Pelin Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Fatih, Turkey aut NATIONALLICENCE 700 1- Sahmay Sezai Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Fatih, Turkey aut NATIONALLICENCE 700 1- Cetin Meral Department of Obstetrics and Gynecology, Cumhuriyet University Medical School, Sivas, Turkey aut NATIONALLICENCE 700 1- Irez Tulay Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Fatih, Turkey aut NATIONALLICENCE 700 1- Guralp Onur Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Fatih, Turkey aut NATIONALLICENCE 700 1- Cepni Ismail Department of Obstetrics and Gynecology, IVF Unit, Cerrahpasa Medical School, Istanbul University, Istanbul, Fatih, Turkey aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/12(2011-12-01), 1197-1203 1058-0468 28:12<1197 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer