caa a22 4500 445817186 CHVBK 20180317145232.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10815-010-9515-3 doi (NATIONALLICENCE)springer-10.1007/s10815-010-9515-3 Pronuclear embryo cryopreservation experience: outcomes for reducing the risk of ovarian hyperstimulation syndrome and for fertility preservation in cancer patients [Elektronische Daten] [Mary Sabatini, Ann Wolkovich, Eric Macklin, Diane Wright, Irene Souter, Thomas Toth] Purpose: To evaluate pregnancy rate (PR) and live birth rate (LBR) after freezing pronuclear (PN) embryos for two purposes: to reduce the risk of ovarian hyperstimulation syndrome (OHSS) and to bank embryos for cancer patients anticipating gametotoxic chemotherapy/radiotherapy. Methods: Data from 3,621 consecutive IVF cycles were retrospectively analyzed. PN freezing was offered to patients at risk for OHSS and for those wishing to preserve fertility prior to cancer therapy. Primary outcomes evaluated were PR and LBR. Outcomes were compared to patients who underwent fresh embryo transfer (ET) in 2006. Results: Sixty-six patients froze PN embryos. Thirty-eight were at risk for OHSS. The LBR was 34.3% after one transfer, and 51.4% after a mean of 1.4 transfers. Twenty-eight cancer patients froze embryos. The LBR was 16.7% after one transfer and 25.0% after a mean of 1.5 transfers. The LBR was 35.5% for patients who underwent fresh ET. Conclusion: PN freezing with delayed ET is an effective tool for achieving pregnancy for patients at risk of OHSS and for cancer patients wishing to preserve fertility. Springer Science+Business Media, LLC, 2010 Ovarian hyperstimulation syndrome nationallicence OHSS nationallicence IVF nationallicence Cancer nationallicence Fertility preservation nationallicence Sabatini Mary Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut Wolkovich Ann Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut Macklin Eric Harvard Medical School, 25 Shattuck Street, 02115, Boston, MA, USA aut Wright Diane Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut Souter Irene Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut Toth Thomas Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/3(2011-03-01), 279-284 1058-0468 28:3<279 2011 28 10815 https://doi.org/10.1007/s10815-010-9515-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9515-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sabatini Mary Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Wolkovich Ann Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Macklin Eric Harvard Medical School, 25 Shattuck Street, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Wright Diane Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Souter Irene Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Toth Thomas Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, 55 Fruit Street, 02114, Boston, MA, USA aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/3(2011-03-01), 279-284 1058-0468 28:3<279 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer