caa a22 4500 445817224 CHVBK 20180317145232.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10815-010-9510-8 doi (NATIONALLICENCE)springer-10.1007/s10815-010-9510-8 Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population [Elektronische Daten] [Mei-Tsz Su, I-Wen Lee, Yi-Chi Chen, Pao-Lin Kuo] Purpose: Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL. Methods: One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331C/T (rs10895068)] of the progesterone receptor gene were genotyped. Results: We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values = 0.006). In addition, the C-C haplotype, which consists of rs590688C > G and rs11224592T > C, is associated with a decreased risk of RPL (p = 0.004). Conclusion: PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women. Springer Science+Business Media, LLC, 2010 Progesterone receptor nationallicence PROGINS nationallicence Recurrent pregnancy loss nationallicence Tag SNP nationallicence Polymorphism nationallicence Su Mei-Tsz Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 138 Sheng-Li Road, 704, Tainan, Taiwan aut Lee I-Wen Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 138 Sheng-Li Road, 704, Tainan, Taiwan aut Chen Yi-Chi Department of Economics, National Cheng Kung University, Tainan, Taiwan aut Kuo Pao-Lin Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 138 Sheng-Li Road, 704, Tainan, Taiwan aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/3(2011-03-01), 239-243 1058-0468 28:3<239 2011 28 10815 https://doi.org/10.1007/s10815-010-9510-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9510-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Su Mei-Tsz Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 138 Sheng-Li Road, 704, Tainan, Taiwan aut NATIONALLICENCE 700 1- Lee I-Wen Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 138 Sheng-Li Road, 704, Tainan, Taiwan aut NATIONALLICENCE 700 1- Chen Yi-Chi Department of Economics, National Cheng Kung University, Tainan, Taiwan aut NATIONALLICENCE 700 1- Kuo Pao-Lin Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 138 Sheng-Li Road, 704, Tainan, Taiwan aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/3(2011-03-01), 239-243 1058-0468 28:3<239 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer