caa a22 4500 445817275 CHVBK 20180317145232.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10815-010-9502-8 doi (NATIONALLICENCE)springer-10.1007/s10815-010-9502-8 Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy [Elektronische Daten] [Tugba Altun, Sangita Jindal, Keri Greenseid, Jun Shu, Lubna Pal] Purpose: Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles. Methods: Follicular fluid was collected from ovarian follicles ≥ 14mm, pooled for each patient, and IL-6 levels were assessed using ELISA (n = 68). Relationships between IL-6 levels and IVF cycle parameters were assessed using nonparametric tests, and between IL-6 levels and clinical pregnancy using multivariable logistic regression analyses. Results: Significant positive correlations were observed between IL-6 with age (p = 0.035), and IL-6 with estradiol on the day of hCG (p = 0.011). On adjusted analyses, IVF cycles in patients with IL-6 levels <4.0pg/ml (median value for the group) demonstrated an almost 4-fold increase in likelihood for clinical pregnancy (p = 0.045). Conclusions: Lower follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. We hypothesize that endometrial receptivity is a likely target for any deleterious influences of elevated IL-6 levels. Springer Science+Business Media, LLC, 2010 IL-6 nationallicence Follicular fluid nationallicence Clinical pregnancy nationallicence IVF nationallicence Altun Tugba Ankara State Research and Training Hospital, Ankara, Turkey aut Jindal Sangita Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology & Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA aut Greenseid Keri Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology & Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA aut Shu Jun Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA aut Pal Lubna Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology & Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/3(2011-03-01), 245-251 1058-0468 28:3<245 2011 28 10815 https://doi.org/10.1007/s10815-010-9502-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9502-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Altun Tugba Ankara State Research and Training Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Jindal Sangita Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology & Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA aut NATIONALLICENCE 700 1- Greenseid Keri Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology & Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA aut NATIONALLICENCE 700 1- Shu Jun Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA aut NATIONALLICENCE 700 1- Pal Lubna Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology & Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/3(2011-03-01), 245-251 1058-0468 28:3<245 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer