caa a22 4500 445817291 CHVBK 20180317145232.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10815-010-9506-4 doi (NATIONALLICENCE)springer-10.1007/s10815-010-9506-4 Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome [Elektronische Daten] [Fariba Ranjzad, Aidin Mahban, Atena Irani Shemirani, Touraj Mahmoudi, Mohsen Vahedi, Abdolrahim Nikzamir, Mohammad Zali] Purpose: The purpose of this study was to evaluate the associations between polymorphisms in vitamin D receptor (VDR), parathyroid hormone (PTH), calcium sensing receptor (CASR), insulin receptor (INSR), and adiponectin (ADIPOQ) genes and biochemical characteristics of women with polycystic ovary syndrome (PCOS). Methods: Serum levels of LH, FSH, estradiol, testosterone, prolactin, SHBG, glucose, IGF-1, IGFBP-1, calcium, phosphorus, PTH, 25(OH)D, and 1,25(OH)2 D were measured in 56 women with PCOS. Furthermore, genotyping five, one, one, two, and two polymorphisms of the VDR, PTH, CASR, INSR, and ADIPOQ genes, respectively, were performed. Results: The VDR TaqI "CC” genotype was associated with elevated serum levels of LH (p = 0.011). There were significant associations between decreased levels of SHBG and both VDR BsmI "GG” (p = 0.009) and ADIPOQ BsmI "CC” (p = 0.016) genotypes. Furthermore, patients with CaSR Hin1I "TG” genotype showed higher HoMA-IR (p = 0.008). All these associations remained significant after Bonferroni correction. In addition, phosphorus correlated negatively with estradiol (r = −0.298, P = 0.026) and positively with glucose (r = 0.287, P = 0.032). Conclusions: These data indicated for the first time that it is possible that the VDR and CASR gene variants through their effects on LH and SHBG levels, and insulin resistance are involved in pathogenesis of PCOS. Springer Science+Business Media, LLC, 2010 Calcium sensing receptor gene nationallicence Phosphorus nationallicence Polycystic ovary syndrome nationallicence Vitamin D receptor gene nationallicence Ranjzad Fariba Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, 1417613151, Tehran, Iran aut Mahban Aidin Research Center for Gastroenterology and Liver Diseases (RCGLD), Shahid Beheshti University of Medical Sciences, Velenjak, Shahid Chamran Highway, 1985711151, Tehran, Iran aut Irani Shemirani Atena Research Center for Gastroenterology and Liver Diseases (RCGLD), Shahid Beheshti University of Medical Sciences, Velenjak, Shahid Chamran Highway, 1985711151, Tehran, Iran aut Mahmoudi Touraj Research Center for Gastroenterology and Liver Diseases (RCGLD), Shahid Beheshti University of Medical Sciences, Velenjak, Shahid Chamran Highway, 1985711151, Tehran, Iran aut Vahedi Mohsen Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, 141556446, Tehran, Iran aut Nikzamir Abdolrahim Department of Biochemistry, Faculty of Medicine, Ahwaz Jondi Shapour University of Medical Sciences, 144545356, Ahwaz, Iran aut Zali Mohammad Research Center for Gastroenterology and Liver Diseases (RCGLD), Shahid Beheshti University of Medical Sciences, Velenjak, Shahid Chamran Highway, 1985711151, Tehran, Iran aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/3(2011-03-01), 225-232 1058-0468 28:3<225 2011 28 10815 https://doi.org/10.1007/s10815-010-9506-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9506-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ranjzad Fariba Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, 1417613151, Tehran, Iran aut NATIONALLICENCE 700 1- Mahban Aidin Research Center for Gastroenterology and Liver Diseases (RCGLD), Shahid Beheshti University of Medical Sciences, Velenjak, Shahid Chamran Highway, 1985711151, Tehran, Iran aut NATIONALLICENCE 700 1- Irani Shemirani Atena Research Center for Gastroenterology and Liver Diseases (RCGLD), Shahid Beheshti University of Medical Sciences, Velenjak, Shahid Chamran Highway, 1985711151, Tehran, Iran aut NATIONALLICENCE 700 1- Mahmoudi Touraj Research Center for Gastroenterology and Liver Diseases (RCGLD), Shahid Beheshti University of Medical Sciences, Velenjak, Shahid Chamran Highway, 1985711151, Tehran, Iran aut NATIONALLICENCE 700 1- Vahedi Mohsen Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, 141556446, Tehran, Iran aut NATIONALLICENCE 700 1- Nikzamir Abdolrahim Department of Biochemistry, Faculty of Medicine, Ahwaz Jondi Shapour University of Medical Sciences, 144545356, Ahwaz, Iran aut NATIONALLICENCE 700 1- Zali Mohammad Research Center for Gastroenterology and Liver Diseases (RCGLD), Shahid Beheshti University of Medical Sciences, Velenjak, Shahid Chamran Highway, 1985711151, Tehran, Iran aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/3(2011-03-01), 225-232 1058-0468 28:3<225 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer