caa a22 4500 445817305 CHVBK 20180317145232.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10815-011-9618-5 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9618-5 p53 codon 72 polymorphism and recurrent pregnancy loss: a meta-analysis [Elektronische Daten] [Wenru Tang, Xuhong Zhou, Ying Chan, Xiaomin Wu, Ying Luo] Background: Arg72Pro polymorphism of the p53 tumour suppressor gene have been associated with recurrent pregnancy loss. However, results were inconsistent. We performed this metaanalysis to drive amore precise estimation of association between p53 codon 72 polymorphism and recurrent pregnancy loss. Methods: Electronic searche of PubMed was conducted to select studies. Case-control studies containing available genotype frequencies of Arg72Pro were chose, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results: 4 case-control studies including 523 cases and 378controls were identified. This meta-analysis showed that individuals with the homozygous Pro/Pro genotype had increased risk of recurrent pregnancy loss (OR = 1.85, 95% CI: 1.078 ~ 3.173, p = 0.025) in the pooled analyses. An symmetric funnel plot, the Egger's test (P = 0.497), and the Begg- test (P = 0.85) were all suggestive of the lack of publication bias. Conclusion: This meta-analysis supports the idea that p53 condon72 Pro/Pro genotype is associated with increased risk of recurrent pregnancy loss. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between p53 codon 72 polymorphism and recurrent pregnancy loss. Springer Science+Business Media, LLC, 2011 p53 nationallicence Meta-analysis nationallicence Recurrent pregnancy loss nationallicence Tang Wenru Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, #296 Bailongsi, 650224, Kunming, Yunnan, China aut Zhou Xuhong Flower Research Institute of Yunnan Academy of Agricultural Sciences, 650205, Kunming, China aut Chan Ying Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, #296 Bailongsi, 650224, Kunming, Yunnan, China aut Wu Xiaomin Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, #296 Bailongsi, 650224, Kunming, Yunnan, China aut Luo Ying Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, #296 Bailongsi, 650224, Kunming, Yunnan, China aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 965-969 1058-0468 28:10<965 2011 28 10815 https://doi.org/10.1007/s10815-011-9618-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9618-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tang Wenru Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, #296 Bailongsi, 650224, Kunming, Yunnan, China aut NATIONALLICENCE 700 1- Zhou Xuhong Flower Research Institute of Yunnan Academy of Agricultural Sciences, 650205, Kunming, China aut NATIONALLICENCE 700 1- Chan Ying Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, #296 Bailongsi, 650224, Kunming, Yunnan, China aut NATIONALLICENCE 700 1- Wu Xiaomin Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, #296 Bailongsi, 650224, Kunming, Yunnan, China aut NATIONALLICENCE 700 1- Luo Ying Lab of Molecular Genetics of Aging & Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, #296 Bailongsi, 650224, Kunming, Yunnan, China aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 965-969 1058-0468 28:10<965 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer