caa a22 4500 445817356 CHVBK 20180317145232.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10815-011-9622-9 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9622-9 Association study of HLA-B alleles with idiopathic male infertility in Han population of China [Elektronische Daten] [Dang-xia Zhou, Jing Zhang, Hai-xu Wang, Xiao-fang Wang, Zhao Tian, Wen-bao Zhao, Shui-ping Han, Jian Zhang, Yong-wei Huo, Hong Tian] Purpose: To investigate the distributions of HLA-B alleles and estimate their associations with idiopathic male infertility in Chinese Han population. Methods: Polymerase chain reaction-sequence-based typing (PCR-SBT) method was used for DNA typing at HLA-B locus in 109 patients with idiopathic male infertility and 152 healthy controls in male Han population of Shaanxi Province, situated in northwestern China. Results: In total, we detected 45 HLA-B alleles in idiopathic infertile patients, 48 HLA-B alleles in control subjects. However, no significant differences of these allelic frequencies were found between the infertile patients and the controls. Conclusion: HLA-B gene was unlikely a major risk factor of idiopathic male infertility in this sample population. As different populations have different HLA polymorphisms, investigation of the relationship of other HLA genes and idiopathic male infertility with larger sample size, is warranted in the future. Springer Science+Business Media, LLC, 2011 Human leukocyte antigen (HLA)-B nationallicence Polymerase chain reaction-sequence-based typing (PCR-SBT) nationallicence Idiopathic male infertility nationallicence Zhou Dang-xia Department of Pathology, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut Zhang Jing Department of Pathology, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut Wang Hai-xu Reproductive Medical Center, Xi'an Jiaotong University, 710061, Xi'an, China aut Wang Xiao-fang Shaan'xi Blood Center, 710061, Xi'an, China aut Tian Zhao Department of Forensic Medicine, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut Zhao Wen-bao Department of Pathology, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut Han Shui-ping Department of Pathology, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut Zhang Jian Department of Pathology, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut Huo Yong-wei Reproductive Medical Center, Xi'an Jiaotong University, 710061, Xi'an, China aut Tian Hong Reproductive Medical Center, Xi'an Jiaotong University, 710061, Xi'an, China aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 979-985 1058-0468 28:10<979 2011 28 10815 https://doi.org/10.1007/s10815-011-9622-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9622-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhou Dang-xia Department of Pathology, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Zhang Jing Department of Pathology, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Wang Hai-xu Reproductive Medical Center, Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Wang Xiao-fang Shaan'xi Blood Center, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Tian Zhao Department of Forensic Medicine, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Zhao Wen-bao Department of Pathology, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Han Shui-ping Department of Pathology, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Zhang Jian Department of Pathology, Medical School, Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Huo Yong-wei Reproductive Medical Center, Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Tian Hong Reproductive Medical Center, Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 979-985 1058-0468 28:10<979 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer