caa a22 4500 445817380 CHVBK 20180317145232.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10815-011-9573-1 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9573-1 Identification of common mechanisms between endometriosis and ovarian cancer [Elektronische Daten] [Qingsong Meng, Weixue Sun, John Jiang, Nicole Fletcher, Michael Diamond, Ghassan Saed] Purpose: To determine common molecular markers between endometriosis and ovarian cancer. Methods: Patients included women who underwent laparoscopic excision of ovarian endometriotic lesions (n = 7), healthy non-pregnant women with normal pelvises, who underwent excision of normal peritoneum (n = 7). Two epithelial ovarian cancer (EOC) cell lines were also utilized. Expression of transforming growth factor (TGF)-β1, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF), estrogen receptor (ER)-1α, progesterone receptor (PR), androgen receptor (AR), and aromatase was evaluated by real-time RT-PCR. Results: Endometriosis and EOC cells manifested significantly higher mRNA levels of TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase, while they expressed significantly lower mRNA levels of PR. Conclusions: Increased TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase and decreased PR in endometriotic as well as EOC cells suggests a potential association between these two disease processes. This association is important, as it may reveal common mechanisms for both diseases. Springer Science+Business Media, LLC, 2011 Endometriosis nationallicence Ovarian cancer nationallicence Hormone receptors nationallicence TGF-β1 nationallicence COX-2 nationallicence VEGF nationallicence Aromatase nationallicence Meng Qingsong Department of Clinical Laboratory, Qianfo Shan Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut Sun Weixue Department of Surgery, Qingdao University School of Medicine, Qingdao, Shandong, People's Republic of China aut Jiang John Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 E. Hancock, 48201, Detroit, MI, USA aut Fletcher Nicole Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 E. Hancock, 48201, Detroit, MI, USA aut Diamond Michael Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 E. Hancock, 48201, Detroit, MI, USA aut Saed Ghassan Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 E. Hancock, 48201, Detroit, MI, USA aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 917-923 1058-0468 28:10<917 2011 28 10815 https://doi.org/10.1007/s10815-011-9573-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9573-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meng Qingsong Department of Clinical Laboratory, Qianfo Shan Hospital, Shandong University, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Sun Weixue Department of Surgery, Qingdao University School of Medicine, Qingdao, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Jiang John Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 E. Hancock, 48201, Detroit, MI, USA aut NATIONALLICENCE 700 1- Fletcher Nicole Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 E. Hancock, 48201, Detroit, MI, USA aut NATIONALLICENCE 700 1- Diamond Michael Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 E. Hancock, 48201, Detroit, MI, USA aut NATIONALLICENCE 700 1- Saed Ghassan Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 E. Hancock, 48201, Detroit, MI, USA aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 917-923 1058-0468 28:10<917 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer