caa a22 4500 445817399 CHVBK 20180317145233.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10815-011-9610-0 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9610-0 Prognostic value of triploid zygotes on intracytoplasmic sperm injection outcomes [Elektronische Daten] [Rita Figueira, Amanda Setti, Daniela Braga, Assumpto Iaconelli Jr., Edson Borges Jr.] Purpose: To evaluate the prognostic significance of triploidy incidence on the outcomes of embryos derived from normally fertilized oocytes from the same cohort. Methods: This study included 1500 ICSI cycles. Logistic regression models were used to study the influence of abnormal fertilization on the development and clinical outcomes of embryos derived from normally fertilized oocytes from the same cohort Results: We observed a negative influence of the percentages of triploid zygotes on fertilization (75.2% and 56.8%, P < 0.0001), high-quality embryos (58.9% and 48.2%, P = 0.0001), pregnancy (34.1% and 28.2%, P = 0.0540) and implantation rates (20.0% and 13.3%, P = 0.0012). When the 3PN zygote rate was >25%, the percentages of normal fertilization, high-quality embryos and implantation rates were significantly lower than in the control group. Conclusions: We observed an approximately 50% lower risk of pregnancy and a 3.5-fold higher risk of miscarriage in cycles with a 3PN incidence of >25%. Springer Science+Business Media, LLC, 2011 Abnormal fertilization nationallicence ICSI nationallicence Triploidy nationallicence 3PN nationallicence Figueira Rita Fertility-Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, Zip code: 01401-002, São Paulo, SP, Brazil aut Setti Amanda Sapientiae Institute-Educational and Research Center in Assisted Reproduction, São Paulo, SP, Brazil aut Braga Daniela Fertility-Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, Zip code: 01401-002, São Paulo, SP, Brazil aut Iaconelli Jr. Assumpto Fertility-Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, Zip code: 01401-002, São Paulo, SP, Brazil aut Borges Jr. Edson Fertility-Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, Zip code: 01401-002, São Paulo, SP, Brazil aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 879-883 1058-0468 28:10<879 2011 28 10815 https://doi.org/10.1007/s10815-011-9610-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9610-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Figueira Rita Fertility-Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, Zip code: 01401-002, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Setti Amanda Sapientiae Institute-Educational and Research Center in Assisted Reproduction, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Braga Daniela Fertility-Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, Zip code: 01401-002, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Iaconelli Jr Assumpto Fertility-Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, Zip code: 01401-002, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Borges Jr Edson Fertility-Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, Zip code: 01401-002, São Paulo, SP, Brazil aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 879-883 1058-0468 28:10<879 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer