caa a22 4500 445817402 CHVBK 20180317145233.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10815-011-9612-y doi (NATIONALLICENCE)springer-10.1007/s10815-011-9612-y The value of human chorionic gonadotropin stimulation test in predicting ovarian response during in-vitro fertilization [Elektronische Daten] [Assaf Ben-Meir, David Shveiky, Einat Zivi, Tomer Feigenberg, Ariel Revel, Alex Simon, Neri Laufer] Purpose: To assess the predictive value of human Chorionic Gonadotropin (hCG) theca-stimulation test for ovarian reserve in women undergoing in-vitro fertilization (IVF) treatments. Methods: 39 women were included in the study. All participants received a single hCG 10000IU injection on cycle day 2-3. Serum levels of estradiol, testosterone, androstenedione and 17-OH progesterone were measured prior to the injection and on days 1, 3 and 7 following the injection. hCG-induced hormone levels were compared with ovarian response during the subsequent IVF cycle. Results: There were 11 good responders (>10 oocytes) and 22 low responders (<3 oocytes). Before hCG stimulation serum E2 levels were higher in low responders compared to good responders (370.3 ± 443 vs. 138.3 ± 54 pmol/ml). Following hCG stimulation, day 3 androstendione levels showed an increase in good responders compared to low responders. The ratio between day 3 androstendione and day 0 estradiol was significantly different between the two groups (p = 0.03). ROC analysis of this test revealed area = 0.837 (good prediction), which was much better than day 3 FSH (area = 0.635, poor prediction). Conclusions: These preliminary results demonstrate the potential use of the hCG theca stimulation test in differentiating between good and poor responders. Larger series are needed for further verification of the test in routine clinical application. Springer Science+Business Media, LLC, 2011 Ovarian reserve nationallicence IVF nationallicence Androgens nationallicence hCG theca stimulation test nationallicence Ben-Meir Assaf The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut Shveiky David The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut Zivi Einat The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut Feigenberg Tomer The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut Revel Ariel The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut Simon Alex The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut Laufer Neri The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 893-899 1058-0468 28:10<893 2011 28 10815 https://doi.org/10.1007/s10815-011-9612-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9612-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ben-Meir Assaf The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Shveiky David The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Zivi Einat The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Feigenberg Tomer The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Revel Ariel The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Simon Alex The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Laufer Neri The Departments of Obstetrics and Gynecology, The Hadassah-Hebrew University Medical Center, Ein-Kerem, POB 12000, 91120, Jerusalem, Israel aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 893-899 1058-0468 28:10<893 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer