caa a22 4500 445817437 CHVBK 20180317145233.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10815-011-9613-x doi (NATIONALLICENCE)springer-10.1007/s10815-011-9613-x The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis [Elektronische Daten] [Wei Wang, Xue-Hong Zhang, Wei-Hua Wang, Ya-Li Liu, Li-Hui Zhao, Shi-Long Xue, Ke-Hu Yang] Objective: To evaluate the relationship between different hCG priming-to-oocyte retrieval intervals and assisted reproductive technology (ART) outcome. Methods: We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index, Chinese biomedicine (CBM) literature database, and Chinese Journal Full-text Database for randomized controlled trials (RCTs) published up to November 2010. Data was extracted from the studies by two independent reviewers. Statistical analysis was performed with Cochrane Collaboration's Review Manager (RevMan) 5.0.2. From extracted data, Risk Ratio (RR) with 95% confidence interval (CI) was calculated. Results: 5 RCTs totaling 895 participants were included. Oocyte maturation rate was higher in the long interval group compared with short interval group (RR, 0.67; 95% CI, 0.62-0.73). There were no significant difference between the two groups with regard to fertilization rate (RR, 0.99; 95% CI, 0.94-1.04), implantation rate (RR, 0.91; 95% CI, 0.40-2.04), and pregnancy rate (RR, 0.79; 95% CI, 0.58-1.08). Conclusion: The percentage of mature (MII) oocytes can be increased by prolonging the interval between hCG priming and oocyte retrieval. The prolonged interval could not increase the fertilization rate, implantation rate, and pregnancy rate. Although there was evidence to confirm the results, they still need to be confirmed by large-sample, multicenter, randomized controlled trials. The time interval dependent mechanisms responsible for ART performance need to be elucidated. Springer Science+Business Media, LLC, 2011 Human chorionic gonadotropin nationallicence Oocyte retrieval nationallicence Time interval nationallicence Infertility nationallicence Assisted reproductive technology nationallicence Meta-analysis nationallicence ART : Assisted reproductive technology nationallicence ATP : Adenosine triphosphate nationallicence CC : Clomiphene citrate nationallicence COH : Controlled ovarian hyperstimulation nationallicence ET : Embryo transfer nationallicence FSH : Follicle-stimulating hormone nationallicence GnRH-a : Gonadotropic hormone releasing hormone analogue nationallicence hCG : Human chorionic gonadotropin nationallicence hMG : Human menopausal gonadotropin nationallicence ICSI : Intracytoplasmic sperm injection nationallicence IGF : Insulin-like growth factor nationallicence IL : Interleukin nationallicence IM : Intramuscular injection nationallicence IUI : Intrauterine insemination nationallicence IVF : In vitro fertilization nationallicence IVM : In vitro maturation nationallicence LH : Luteinizing hormone nationallicence LI : Long interval nationallicence MII : Metaphase II nationallicence NA : Not available nationallicence RCT : Randomized controlled trial nationallicence RevMan : Review Manager nationallicence RR : Risk ratio nationallicence SI : Short interval nationallicence TUS : Transvaginal ultrasound nationallicence VEGF : Vascular endothelial growth factor nationallicence 2PN : Two-pronuclear nationallicence 95% CI : 95% confidence interval nationallicence Wang Wei The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China aut Zhang Xue-Hong The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China aut Wang Wei-Hua The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China aut Liu Ya-Li The Evidence-Based Medicine Center of Lanzhou University, Lanzhou, China aut Zhao Li-Hui The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China aut Xue Shi-Long The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China aut Yang Ke-Hu The Evidence-Based Medicine Center of Lanzhou University, Lanzhou, China aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 901-910 1058-0468 28:10<901 2011 28 10815 https://doi.org/10.1007/s10815-011-9613-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9613-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Wei The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China aut NATIONALLICENCE 700 1- Zhang Xue-Hong The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China aut NATIONALLICENCE 700 1- Wang Wei-Hua The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China aut NATIONALLICENCE 700 1- Liu Ya-Li The Evidence-Based Medicine Center of Lanzhou University, Lanzhou, China aut NATIONALLICENCE 700 1- Zhao Li-Hui The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China aut NATIONALLICENCE 700 1- Xue Shi-Long The Reproductive Medicine Center, the First Hospital of Lanzhou University, Lanzhou, China aut NATIONALLICENCE 700 1- Yang Ke-Hu The Evidence-Based Medicine Center of Lanzhou University, Lanzhou, China aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/10(2011-09-01), 901-910 1058-0468 28:10<901 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer