caa a22 4500 445817542 CHVBK 20180317145233.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10815-011-9552-6 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9552-6 Advancements in reprogramming strategies for the generation of induced pluripotent stem cells [Elektronische Daten] [Mei Lai, Wai Wendy-Yeo, Rajesh Ramasamy, Norshariza Nordin, Rozita Rosli, Abhi Veerakumarasivam, Syahril Abdullah] Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells has emerged as an invaluable method for generating patient-specific stem cells of any lineage without the use of embryonic materials. Following the first reported generation of iPS cells from murine fibroblasts using retroviral transduction of a defined set of transcription factors, various new strategies have been developed to improve and refine the reprogramming technology. Recent developments provide optimism that the generation of safe iPS cells without any genomic modification could be derived in the near future for the use in clinical settings. This review summarizes current and evolving strategies in the generation of iPS cells, including types of somatic cells for reprogramming, variations of reprogramming genes, reprogramming methods, and how the advancement iPS cells technology can lead to the future success of reproductive medicine. Springer Science+Business Media, LLC, 2011 Induced pluripotent stem cell nationallicence Reprogramming strategies nationallicence Lai Mei Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, Serdang UPM, Selangor, Malaysia aut Wendy-Yeo Wai Medical Genetics Laboratory, Clinical Genetics Unit, Laboratory Block B, Level 6, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia aut Ramasamy Rajesh Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, Serdang UPM, Selangor, Malaysia aut Nordin Norshariza Stem Cell Research Laboratory, Laboratory Block D, Level 7, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, Serdang UPM, Selangor, Malaysia aut Rosli Rozita Medical Genetics Laboratory, Clinical Genetics Unit, Laboratory Block B, Level 6, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia aut Veerakumarasivam Abhi Medical Genetics Laboratory, Clinical Genetics Unit, Laboratory Block B, Level 6, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia aut Abdullah Syahril Medical Genetics Laboratory, Clinical Genetics Unit, Laboratory Block B, Level 6, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/4(2011-04-01), 291-301 1058-0468 28:4<291 2011 28 10815 https://doi.org/10.1007/s10815-011-9552-6 text/html Onlinezugriff via DOI 1 editorial jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9552-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lai Mei Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, Serdang UPM, Selangor, Malaysia aut NATIONALLICENCE 700 1- Wendy-Yeo Wai Medical Genetics Laboratory, Clinical Genetics Unit, Laboratory Block B, Level 6, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia aut NATIONALLICENCE 700 1- Ramasamy Rajesh Department of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, Serdang UPM, Selangor, Malaysia aut NATIONALLICENCE 700 1- Nordin Norshariza Stem Cell Research Laboratory, Laboratory Block D, Level 7, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, Serdang UPM, Selangor, Malaysia aut NATIONALLICENCE 700 1- Rosli Rozita Medical Genetics Laboratory, Clinical Genetics Unit, Laboratory Block B, Level 6, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia aut NATIONALLICENCE 700 1- Veerakumarasivam Abhi Medical Genetics Laboratory, Clinical Genetics Unit, Laboratory Block B, Level 6, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia aut NATIONALLICENCE 700 1- Abdullah Syahril Medical Genetics Laboratory, Clinical Genetics Unit, Laboratory Block B, Level 6, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/4(2011-04-01), 291-301 1058-0468 28:4<291 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer