caa a22 4500 445817593 CHVBK 20180317145233.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10815-011-9576-y doi (NATIONALLICENCE)springer-10.1007/s10815-011-9576-y Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest [Elektronische Daten] [Toshinobu Miyamoto, Akira Tsujimura, Yasushi Miyagawa, Eitetsu Koh, Mikio Namiki, Michiharu Horikawa, Yasuaki Saijo, Kazuo Sengoku] Purpose: To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest. Methods: Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls. Results: The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001). Conclusion: The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest. Springer Science+Business Media, LLC, 2011 Azoospermia nationallicence Meiotic arrest nationallicence UBR2 nationallicence Polymorphism nationallicence Miyamoto Toshinobu Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan aut Tsujimura Akira Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan aut Miyagawa Yasushi Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan aut Koh Eitetsu Department of Integrated Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan aut Namiki Mikio Department of Integrated Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan aut Horikawa Michiharu Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan aut Saijo Yasuaki Division of Community Medicine and Epidemiology, Department of Health Science, Asahikawa Medical University, Asahikawa, Japan aut Sengoku Kazuo Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/8(2011-08-01), 743-746 1058-0468 28:8<743 2011 28 10815 https://doi.org/10.1007/s10815-011-9576-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9576-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miyamoto Toshinobu Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan aut NATIONALLICENCE 700 1- Tsujimura Akira Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan aut NATIONALLICENCE 700 1- Miyagawa Yasushi Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan aut NATIONALLICENCE 700 1- Koh Eitetsu Department of Integrated Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan aut NATIONALLICENCE 700 1- Namiki Mikio Department of Integrated Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan aut NATIONALLICENCE 700 1- Horikawa Michiharu Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan aut NATIONALLICENCE 700 1- Saijo Yasuaki Division of Community Medicine and Epidemiology, Department of Health Science, Asahikawa Medical University, Asahikawa, Japan aut NATIONALLICENCE 700 1- Sengoku Kazuo Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/8(2011-08-01), 743-746 1058-0468 28:8<743 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 445817593 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer