caa a22 4500 445817631 CHVBK 20180317145233.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10815-011-9577-x doi (NATIONALLICENCE)springer-10.1007/s10815-011-9577-x Umbilical cord blood banking: an update [Elektronische Daten] [Merlin Butler, Jay Menitove] Background: Umbilical cord blood is a potential vast source of primitive hematopoietic stem and progenitor cells available for clinical application to reconstitute the hematopoietic system and/or restore immunological function in affected individuals requiring treatment. Cord blood can be used as an alternative source for bone marrow transplantation and its use is developing into a new field of treatment for pediatric and adult patients presenting with hematological disorders, immunological defects and specific genetic diseases. Discussion: More than 25,000 allogeneic cord blood transplantations have been performed worldwide since the first cord blood transplantation in 1988. There are two banking options for storing umbilical cord blood [private (family) and public]. Cord blood stored in private banks are used for either autologous or allogeneic transplants for the infant donor or related family members but private cord blood banks are not searchable or available to the public. More than 780,000 cord blood units are stored in over 130 private cord blood banks, worldwide, and over 400,000 units in more than 100 quality controlled public cord blood banks. Conclusions: Researchers continue to evaluate the usefulness of cord blood cells in treating human diseases or disorders for purposes other than hematological disorders including heart disease, strokes, brain or spinal cord injuries and cancer. This review summarizes the status of umbilical cord blood banking, its history and current and potential use in the treatment of human disease. Springer Science+Business Media, LLC, 2011 Umbilical cord blood nationallicence Public and private cord blood banks nationallicence Transplantation nationallicence Clinical applications nationallicence Regenerative medicine nationallicence Butler Merlin Departments of Psychiatry & Behavioral Sciences and Pediatrics, Kansas University Medical Center, 3901 Rainbow Blvd, MS 4015, 66160, Kansas City, KS, USA aut Menitove Jay Community Blood Center of Greater Kansas City, Kansas City, MO, USA aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/8(2011-08-01), 669-676 1058-0468 28:8<669 2011 28 10815 https://doi.org/10.1007/s10815-011-9577-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9577-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Butler Merlin Departments of Psychiatry & Behavioral Sciences and Pediatrics, Kansas University Medical Center, 3901 Rainbow Blvd, MS 4015, 66160, Kansas City, KS, USA aut NATIONALLICENCE 700 1- Menitove Jay Community Blood Center of Greater Kansas City, Kansas City, MO, USA aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/8(2011-08-01), 669-676 1058-0468 28:8<669 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer