caa a22 4500 445817704 CHVBK 20180317145234.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10815-011-9570-4 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9570-4 Different ART outcomes at increasing peak estradiol levels with long and antagonist protocols: retrospective insights from ten years experience [Elektronische Daten] [Massimo Manno, Marta Cervi, Donatella Zadro, Giuseppa Fuggetta, Valter Adamo, Francesco Tomei] Purpose: To evaluate the impact of high estradiol (E2) levels on assisted reproductive technologies outcomes in high responders (≥12 oocytes retrieved) according to the controlled ovarian stimulation protocol (COS) used. Methods: Clinical retrospective evaluation of total, clinical pregnancy and implantation rates in ART cycles performed in high responders according to the COS protocol used (long or antagonist) at Pathophysiology Unit of Human Reproduction and Sperm Bank of Pordenone from June 2000 to December 2010. Results: In high responders total, clinical and implantation rates were significantly higher in long if compared with antagonist protocol with peak estradiol level ≤3,000pg/ml; on the contrary there was a significantly higher implantation rate with antagonist than long protocol with peak estradiol >3,000pg/ml. However in this subgroup of patients total and clinical pregnancy rates showed only a trend favouring antagonist possibly due to a statistical β error. Conclusions: In high responders long protocol seems to work better than antagonist when peak E2 is lower than 3,000pg/ml but the opposite may be true for cycles with higher E2 levels. Springer Science+Business Media, LLC, 2011 Peak estradiol levels nationallicence Endometrium nationallicence Implantation rate nationallicence Pregnancy rate nationallicence GnRH agonists nationallicence GnRH antagonists nationallicence Manno Massimo Pathophysiology Unit of Human Reproduction and Sperm Bank, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut Cervi Marta Pathophysiology Unit of Human Reproduction and Sperm Bank, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut Zadro Donatella Pathophysiology Unit of Human Reproduction and Sperm Bank, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut Fuggetta Giuseppa Pathophysiology Unit of Human Reproduction and Sperm Bank, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut Adamo Valter Obstetric and Gynecology Unit, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut Tomei Francesco Pathophysiology Unit of Human Reproduction and Sperm Bank, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/8(2011-08-01), 693-698 1058-0468 28:8<693 2011 28 10815 https://doi.org/10.1007/s10815-011-9570-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9570-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Manno Massimo Pathophysiology Unit of Human Reproduction and Sperm Bank, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut NATIONALLICENCE 700 1- Cervi Marta Pathophysiology Unit of Human Reproduction and Sperm Bank, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut NATIONALLICENCE 700 1- Zadro Donatella Pathophysiology Unit of Human Reproduction and Sperm Bank, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut NATIONALLICENCE 700 1- Fuggetta Giuseppa Pathophysiology Unit of Human Reproduction and Sperm Bank, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut NATIONALLICENCE 700 1- Adamo Valter Obstetric and Gynecology Unit, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut NATIONALLICENCE 700 1- Tomei Francesco Pathophysiology Unit of Human Reproduction and Sperm Bank, Mother and Child Department, Pordenone Hospital, Azienda S. Maria degli Angeli, via Montereale 24, 33170, Pordenone, Italy aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/8(2011-08-01), 693-698 1058-0468 28:8<693 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer