caa a22 4500 445817747 CHVBK 20180317145234.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10815-011-9544-6 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9544-6 Is sperm dna damage associated with IVF embryo quality? A systematic review [Elektronische Daten] [Armand Zini, Wael Jamal, Lisa Cowan, Naif Al-Hathal] Purpose: Sperm DNA damage is common amongst infertile men and may adversely impact natural reproduction, IUI-assisted reproduction and to a lesser degree IVF pregnancy. The objective of this study was to examine the influence of sperm DNA damage on embryo quality and/or development at IVF and ICSI. Methods: We conducted a systematic review of studies that evaluated sperm DNA damage and embryo development and/or quality after IVF and/or ICSI. Results: We identified 28 studies (8 IVF, 12 ICSI and 8 mixed IVF-ICSI studies) that evaluated the relationship between sperm DNA damage and embryo quality. These 28 studies evaluated 3226 treatment cycles (1033 IVF and 873 ICSI, 1320 mixed IVF-ICSI cycles) and demonstrated highly variable characteristics. In 11 of the 28 studies (1/8 IVF, 5/12 ICSI and 5/8 mixed IVF-ICSI studies), sperm DNA damage was associated with poor embryo quality and/or development, whereas the remaining 17 studies showed no relationship between sperm DNA damage and embryo quality and/or development. Conclusions: This systematic review indicates that the evaluable studies are heterogeneous and that overall, there is no consistent relationship between sperm DNA damage and embryo quality and/or development. The data also suggest that the influence of sperm DNA damage on embryo quality/development may be more significant in ICSI compared to IVF cycles. Springer Science+Business Media, LLC, 2011 Spermatozoa nationallicence Sperm DNA nationallicence Embryo nationallicence Pregnancy nationallicence In vitro fertilization nationallicence Zini Armand Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada aut Jamal Wael Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada aut Cowan Lisa The Victoria Fertility Centre, Victoria, British Columbia, Canada aut Al-Hathal Naif Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/5(2011-05-01), 391-397 1058-0468 28:5<391 2011 28 10815 https://doi.org/10.1007/s10815-011-9544-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9544-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zini Armand Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Jamal Wael Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Cowan Lisa The Victoria Fertility Centre, Victoria, British Columbia, Canada aut NATIONALLICENCE 700 1- Al-Hathal Naif Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/5(2011-05-01), 391-397 1058-0468 28:5<391 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer