caa a22 4500 445817755 CHVBK 20180317145234.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10815-011-9542-8 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9542-8 Primary male infertility in Izmir/Turkey: a cytogenetic and molecular study of 187 infertile Turkish patients [Elektronische Daten] [Haluk Akin, Huseyin Onay, Emre Turker, Ferda Ozkinay] Purpose: To detect somatic cytogenetic abnormalities and AZF microdeletions in a sample of 187 Turkish infertile men to determine the frequencies and the characteristics of our primary male infertility data in order to perform appropriate genetic counseling. Methods: This study included 187 infertile men. Chromosomal studies and screening of AZF deletions was performed by multiplex polymerase chain reaction (PCR) analysis using the Y Chromosome Deletion Detection System. Results: Cytogenetic study revealed chromosomal abnormality in 9 subjects (4.8%). In remaining 178 subjects, 7 subjects (3.93%) were detected to have Y chromosome microdeletions. The AZFc region was the most frequently involved region in microdeletion process in affected subjects. All subjects having microdeletion were azoospermic Conclusions: Cytogenetic and molecular study should be performed to obtain reliable genetic information for the genetic counseling of primary infertile man. Y chromosome microdeletion diagnosis is useful in decision making for assisted reproductive technics. Springer Science+Business Media, LLC, 2011 Primary male infertiliy nationallicence Genetic factors nationallicence Y chromosome nationallicence Microdeletions nationallicence Akin Haluk Department of Medical Genetics School of Medicine, Ege University, Izmır, Turkey aut Onay Huseyin Department of Medical Genetics School of Medicine, Ege University, Izmır, Turkey aut Turker Emre Department of Medical Genetics School of Medicine, Ege University, Izmır, Turkey aut Ozkinay Ferda Department of Medical Genetics School of Medicine, Ege University, Izmır, Turkey aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/5(2011-05-01), 419-423 1058-0468 28:5<419 2011 28 10815 https://doi.org/10.1007/s10815-011-9542-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9542-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akin Haluk Department of Medical Genetics School of Medicine, Ege University, Izmır, Turkey aut NATIONALLICENCE 700 1- Onay Huseyin Department of Medical Genetics School of Medicine, Ege University, Izmır, Turkey aut NATIONALLICENCE 700 1- Turker Emre Department of Medical Genetics School of Medicine, Ege University, Izmır, Turkey aut NATIONALLICENCE 700 1- Ozkinay Ferda Department of Medical Genetics School of Medicine, Ege University, Izmır, Turkey aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/5(2011-05-01), 419-423 1058-0468 28:5<419 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer