caa a22 4500 445817801 CHVBK 20180317145234.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10815-010-9516-2 doi (NATIONALLICENCE)springer-10.1007/s10815-010-9516-2 Are poor responders patients at higher risk for producing aneuploid embryos in vitro? [Elektronische Daten] [Amanda Setti, Daniela Braga, Rita de Figueira, Matheus de Azevedo, Assumpto Iaconelli Jr., Edson Borges Jr.] Purpose: To test the hypothesis that aged women with poor ovarian response express an increase on embryo chromosomal alterations when compared to aged women who presented normal response. Methods: Couples undergoing intracytoplasmic sperm injection cycles with preimplantation genetic screening, were subdivided into two groups: Poor Responder group (n = 34), patients who produced ≤4 oocytes; and Normoresponder group (n = 50), patients who produced ≥5 oocytes. Groups were compared regarding cycles' outcomes and aneuploidy frequency. Results: There were no significant differences between and groups regarding the fertilization rate (p = 0.6861), clinical pregnancy (p = 0.9208), implantation (p = 0.6863), miscarriage (p = 0.6788) and the percentage of aneuploid embryos (p = 0.270). Embryo transfer rate was significantly lower on poor responder group (p = 0.0128) and logistic regression confirmed the influence of poor response on the chance of embryo transfer (p = 0.016). Conclusions: Aged females responding poorly to gonadotrophins are not at a higher risk for producing aneuploid embryos in vitro. Springer Science+Business Media, LLC, 2010 Intracytoplasmic sperm injection nationallicence Ovarian stimulation nationallicence Poor ovarian response nationallicence Preimplantation genetic screening nationallicence Setti Amanda Sapientiae Institute - Educational and Research Center in Assisted Reproduction, Rua Vieira Maciel, 62, 04503-040, São Paulo, SP, Brazil aut Braga Daniela Sapientiae Institute - Educational and Research Center in Assisted Reproduction, Rua Vieira Maciel, 62, 04503-040, São Paulo, SP, Brazil aut Figueira Rita de Fertility - Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, 01401-002, São Paulo, SP, Brazil aut Azevedo Matheus de Fertility - Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, 01401-002, São Paulo, SP, Brazil aut Iaconelli Jr. Assumpto Fertility - Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, 01401-002, São Paulo, SP, Brazil aut Borges Jr. Edson Sapientiae Institute - Educational and Research Center in Assisted Reproduction, Rua Vieira Maciel, 62, 04503-040, São Paulo, SP, Brazil aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/5(2011-05-01), 399-404 1058-0468 28:5<399 2011 28 10815 https://doi.org/10.1007/s10815-010-9516-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9516-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Setti Amanda Sapientiae Institute - Educational and Research Center in Assisted Reproduction, Rua Vieira Maciel, 62, 04503-040, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Braga Daniela Sapientiae Institute - Educational and Research Center in Assisted Reproduction, Rua Vieira Maciel, 62, 04503-040, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Figueira Rita de Fertility - Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, 01401-002, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Azevedo Matheus de Fertility - Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, 01401-002, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Iaconelli Jr Assumpto Fertility - Assisted Fertilization Center, Av. Brigadeiro Luis Antônio, 4545, 01401-002, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Borges Jr Edson Sapientiae Institute - Educational and Research Center in Assisted Reproduction, Rua Vieira Maciel, 62, 04503-040, São Paulo, SP, Brazil aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/5(2011-05-01), 399-404 1058-0468 28:5<399 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer