caa a22 4500 445817879 CHVBK 20180317145234.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10815-011-9535-7 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9535-7 Developmental competence of antral follicles and their oocytes after gonadotrophin treatment of sows with gene polymorphisms for leptin and melanocortin receptors (Iberian pig) [Elektronische Daten] [Jorge Muñoz-Frutos, Teresa Encinas, Pilar Pallares, Laura Torres-Rovira, Pedro Gonzalez-Añover, Emilio Gomez-Izquierdo, Raul Sanchez-Sanchez, Antonio Gonzalez-Bulnes] Purpose: To evaluate possible differences in follicle and oocyte developmental competence after gonadotrophin treatment in sows of obese and lean genotypes. Methods: Follicle dynamics, ovulation rate and oocyte developmental competence to embryo were compared between females, of obese (n = 7) and lean genotypes (n = 10), treated with 1,250I.U. of eCG and 500I.U. of hCG. Results: The obese genotype showed lower numbers of follicles growing to preovulatory stages (12.4 ± 1.8 vs 18.6 ± 1.0, P < 0.05), of corpora lutea (16.0 ± 0.9 vs 23.5 ± 0.9, P < 0.05), and of recovered oocytes/embryos (8.0 ± 1.3 vs 12.9 ± 0.9, P < 0.05). Thereafter, embryo viability rates also decreased when compared to lean genotypes (62.5 vs 77.6%, P < 0.05). Discussion: To our knowledge, this is the first study analyzing the effect of obese genotypes on the ovarian response to exogenous gonadotrophins in a non-rodent animal model, the pig. A lower efficiency of gonadotrophin treatments for stimulation of follicle development and induction of ovulation was observed. Springer Science+Business Media, LLC, 2011 Follicle nationallicence Gonadotrophins nationallicence Obesity nationallicence Oocyte nationallicence Swine nationallicence Muñoz-Frutos Jorge ACOMPOR PIGS, Segovia, Spain aut Encinas Teresa Departamento de Toxicologia y Farmacologia, Facultad de Veterinaria, UCM, Madrid, Spain aut Pallares Pilar Dpto. de Reproducción Animal, INIA, Avda. Puerta de Hierro s/n., 28040, Madrid, Spain aut Torres-Rovira Laura Dpto. de Reproducción Animal, INIA, Avda. Puerta de Hierro s/n., 28040, Madrid, Spain aut Gonzalez-Añover Pedro NUTEGA, Madrid, Spain aut Gomez-Izquierdo Emilio Centro de Pruebas de Porcino, ITACyL, Segovia, Spain aut Sanchez-Sanchez Raul Dpto. de Reproducción Animal, INIA, Avda. Puerta de Hierro s/n., 28040, Madrid, Spain aut Gonzalez-Bulnes Antonio Dpto. de Reproducción Animal, INIA, Avda. Puerta de Hierro s/n., 28040, Madrid, Spain aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/5(2011-05-01), 437-443 1058-0468 28:5<437 2011 28 10815 https://doi.org/10.1007/s10815-011-9535-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9535-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muñoz-Frutos Jorge ACOMPOR PIGS, Segovia, Spain aut NATIONALLICENCE 700 1- Encinas Teresa Departamento de Toxicologia y Farmacologia, Facultad de Veterinaria, UCM, Madrid, Spain aut NATIONALLICENCE 700 1- Pallares Pilar Dpto. de Reproducción Animal, INIA, Avda. Puerta de Hierro s/n., 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Torres-Rovira Laura Dpto. de Reproducción Animal, INIA, Avda. Puerta de Hierro s/n., 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Gonzalez-Añover Pedro NUTEGA, Madrid, Spain aut NATIONALLICENCE 700 1- Gomez-Izquierdo Emilio Centro de Pruebas de Porcino, ITACyL, Segovia, Spain aut NATIONALLICENCE 700 1- Sanchez-Sanchez Raul Dpto. de Reproducción Animal, INIA, Avda. Puerta de Hierro s/n., 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Gonzalez-Bulnes Antonio Dpto. de Reproducción Animal, INIA, Avda. Puerta de Hierro s/n., 28040, Madrid, Spain aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/5(2011-05-01), 437-443 1058-0468 28:5<437 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer