caa a22 4500 445817941 CHVBK 20180317145234.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10815-010-9499-z doi (NATIONALLICENCE)springer-10.1007/s10815-010-9499-z The effect of age on in vitro fertilization outcome: is too young possible? [Elektronische Daten] [Zohreh Nazemian, Navid Esfandiari, Murid Javed, Robert Casper] Purpose: The negative correlation between fecundity and age in women has been extensively documented although data on reproductive performance in very young women is sparse. The objective of this study was to determine whether age ≤25years has an impact on reproductive outcome in women undergoing IVF-ET. Methods: IVF outcome in 85 infertility patients aged 19-25years was compared to that in 69 infertility patients aged 30-35years. Primary outcomes included fertilization rates and embryo quality. Secondary outcomes were clinical pregnancy and miscarriage rates. Results: The young patients (≤25years) demonstrated a lower fertilization rate, and reduced number of top quality embryos. Although clinical pregnancy, and implantation rates were similar to their older counterparts (30-35years), the young women had a significantly higher miscarriage rate. Conclusion: Our results demonstrating poorer reproductive performance in very young patients were surprising and need further investigation. Springer Science+Business Media, LLC, 2010 In vitro fertilization nationallicence Young patients nationallicence Pregnancy nationallicence Egg donor nationallicence Reproductive outcome nationallicence Nazemian Zohreh Toronto Centre for Advanced Reproductive Technology (TCART), University of Toronto, 210-150 Bloor Street West, M5S 2X9, Toronto, ON, Canada aut Esfandiari Navid Toronto Centre for Advanced Reproductive Technology (TCART), University of Toronto, 210-150 Bloor Street West, M5S 2X9, Toronto, ON, Canada aut Javed Murid Toronto Centre for Advanced Reproductive Technology (TCART), University of Toronto, 210-150 Bloor Street West, M5S 2X9, Toronto, ON, Canada aut Casper Robert Toronto Centre for Advanced Reproductive Technology (TCART), University of Toronto, 210-150 Bloor Street West, M5S 2X9, Toronto, ON, Canada aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/2(2011-02-01), 101-106 1058-0468 28:2<101 2011 28 10815 https://doi.org/10.1007/s10815-010-9499-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9499-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nazemian Zohreh Toronto Centre for Advanced Reproductive Technology (TCART), University of Toronto, 210-150 Bloor Street West, M5S 2X9, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Esfandiari Navid Toronto Centre for Advanced Reproductive Technology (TCART), University of Toronto, 210-150 Bloor Street West, M5S 2X9, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Javed Murid Toronto Centre for Advanced Reproductive Technology (TCART), University of Toronto, 210-150 Bloor Street West, M5S 2X9, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Casper Robert Toronto Centre for Advanced Reproductive Technology (TCART), University of Toronto, 210-150 Bloor Street West, M5S 2X9, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/2(2011-02-01), 101-106 1058-0468 28:2<101 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer