caa a22 4500 44581795X CHVBK 20180317145234.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10815-010-9492-6 doi (NATIONALLICENCE)springer-10.1007/s10815-010-9492-6 Cytogenetic abnormalities in 1162 couples with recurrent miscarriages in Southern region of India: report and review [Elektronische Daten] [Usha Dutta, P. Rajitha, Vijaya Pidugu, Ashwin Dalal] Purpose: The purpose of the present study was to investigate the contribution of chromosomal anomalies and the frequency of a particular type of aberration in couples with recurrent miscarriages. Methods: A total of 1,162 couples with recurrent miscarriages were analyzed using G-banding and Fluorescence in situ hybridization where ever necessary. Results: Chromosomal anomalies were detected in 78 cases. This study describes majority of the cases with balanced reciprocal translocations. Among the abnormal karyotypes we also report for the first time three unique translocations involving (3;14), (18;22) and (X;22) chromosomes which were confirmed by molecular cytogenetic methods. Conclusions: The review of literature and the overall incidence of the abnormalities suggest that chromosomal analysis in couples with recurrent miscarriages should be taken up by all the practioners at all levels. This not only helps to check the cytological abnormalities but also helps to correlate the recurrent abnormalities in a given population. Thus establishing and correlating the environmental and genetic condition of that particular phenotype and genotype. Springer Science+Business Media, LLC, 2010 Breakpoints nationallicence Chromosomal abnormalities nationallicence Recurrent miscarriages nationallicence Translocations nationallicence Dutta Usha Diagnostics Division, Center for DNA Fingerprinting and Diagnostics, Tuljaguda complex, 4-1-714, 500 001, Hyderabad, Andhra-Pradesh, India aut Rajitha P. Diagnostics Division, Center for DNA Fingerprinting and Diagnostics, Tuljaguda complex, 4-1-714, 500 001, Hyderabad, Andhra-Pradesh, India aut Pidugu Vijaya Diagnostics Division, Center for DNA Fingerprinting and Diagnostics, Tuljaguda complex, 4-1-714, 500 001, Hyderabad, Andhra-Pradesh, India aut Dalal Ashwin Diagnostics Division, Center for DNA Fingerprinting and Diagnostics, Tuljaguda complex, 4-1-714, 500 001, Hyderabad, Andhra-Pradesh, India aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/2(2011-02-01), 145-149 1058-0468 28:2<145 2011 28 10815 https://doi.org/10.1007/s10815-010-9492-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-010-9492-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dutta Usha Diagnostics Division, Center for DNA Fingerprinting and Diagnostics, Tuljaguda complex, 4-1-714, 500 001, Hyderabad, Andhra-Pradesh, India aut NATIONALLICENCE 700 1- Rajitha P. Diagnostics Division, Center for DNA Fingerprinting and Diagnostics, Tuljaguda complex, 4-1-714, 500 001, Hyderabad, Andhra-Pradesh, India aut NATIONALLICENCE 700 1- Pidugu Vijaya Diagnostics Division, Center for DNA Fingerprinting and Diagnostics, Tuljaguda complex, 4-1-714, 500 001, Hyderabad, Andhra-Pradesh, India aut NATIONALLICENCE 700 1- Dalal Ashwin Diagnostics Division, Center for DNA Fingerprinting and Diagnostics, Tuljaguda complex, 4-1-714, 500 001, Hyderabad, Andhra-Pradesh, India aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/2(2011-02-01), 145-149 1058-0468 28:2<145 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer