caa a22 4500 445818069 CHVBK 20180317145235.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10815-011-9642-5 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9642-5 Contribution of cryopreservation in a mandatory SET policy: analysis of 5years of application of law in an academic IVF center [Elektronische Daten] [Yaacoub Salame, Fabienne Devreker, Romain Imbert, Anne Delbaere, Nicolas Fontenelle, Yvon Englert] Objective: To analyse treatment outcomes after SET law enforcement and to evaluate the contribution of cryopreservation in a SET policy. Material: Embryo transfer cycles performed after the law enforcement (SET period) was retrospectively compared to the cycles performed before the law enforcement (DET period). Results: Pregnancy and delivery rates after fresh transfer of SET and DET periods were comparable (31.7% versus 33.3% and 24.5% versus 26.2%, respectively, NS). Overall twin delivery rate is significantly decreased after the law enforcement (11.3% versus 22.4%, p < 0.001) but not in patients aged 36 to 39years (20.3% versus 24%, NS). Frozen-thawed embryo cycles allowed similar cumulative pregnancy rate (30.6%, NS). Taking into account all frozen embryos still to be transferred, SET period offers a better overall pregnancy rate than the DET period (36.1% versus 32.3%, p < 0.01). Conclusions: The Belgian law allowed a dramatic reduction of twin deliveries especially for patients under 36years. Cryopreservation maintains a similar cumulative pregnancy rate. Springer Science+Business Media, LLC, 2011 Single embryo transfer nationallicence Twin pregnancies nationallicence Cryopreservation nationallicence Salame Yaacoub Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium aut Devreker Fabienne Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium aut Imbert Romain Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium aut Delbaere Anne Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium aut Fontenelle Nicolas Research laboratory on Human Reproduction, medicine faculty, Université Libre de Bruxelles, Campus Erasme, Route de Lennik, 1070, Brussels, Belgium aut Englert Yvon Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/11(2011-11-01), 1059-1066 1058-0468 28:11<1059 2011 28 10815 https://doi.org/10.1007/s10815-011-9642-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9642-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Salame Yaacoub Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium aut NATIONALLICENCE 700 1- Devreker Fabienne Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium aut NATIONALLICENCE 700 1- Imbert Romain Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium aut NATIONALLICENCE 700 1- Delbaere Anne Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium aut NATIONALLICENCE 700 1- Fontenelle Nicolas Research laboratory on Human Reproduction, medicine faculty, Université Libre de Bruxelles, Campus Erasme, Route de Lennik, 1070, Brussels, Belgium aut NATIONALLICENCE 700 1- Englert Yvon Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/11(2011-11-01), 1059-1066 1058-0468 28:11<1059 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer