caa a22 4500 44581814X CHVBK 20180317145235.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10815-011-9643-4 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9643-4 Does the addition of clomiphene citrate or letrazole to gonadotropin treatment enhance the oocyte yield in poor responders undergoing IVF? [Elektronische Daten] [Vuk Jovanovic, Daniel Kort, Michael Guarnaccia, Mark Sauer, Rogerio Lobo] Purpose: To evaluate the effect of adjunctive letrazole or clomiphene in IVF stimulation protocols. Methods: A retrospective analysis of high dose GnRH antagonist IVF cycles (450-600IU of gonadotropins) that have met poor responder criteria. Selected consecutive cycles in same patients differed solely in presence or absence of adjunctive clomiphene or letrazole. Results: Supplementation with clomiphene citrate in poor responders showed significant improvements (p < 0.05) in estradiol levels (1506 vs. 1044pg/ml), number of dominant follicles (5.6 vs. 3.9), oocytes retrieved (5.2 vs. 3.4) and number of transferred embryos (1.7 vs. 1.1). It significantly improved biochemical pregnancy rates (18.1% vs. 5.9%) while reducing cycle cancellations (11.7% vs. 32.6%). Letrozole supplementation showed similar effects. Conclusion: Both Clomiphene and Letrazole performed similarly and showed significant effects. However, despite increasing oocyte yield and embryo transfer rates, the overall clinical and live birth rate in this population remained low and showed no measurable increase. Springer Science+Business Media, LLC, 2011 IVF nationallicence Poor responders nationallicence Clomiphene citrate nationallicence Aromatize inhibitors nationallicence Letrazole nationallicence Jovanovic Vuk Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W168th Street, PH-16, 10032, New York, NY, USA aut Kort Daniel Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W168th Street, PH-16, 10032, New York, NY, USA aut Guarnaccia Michael Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W168th Street, PH-16, 10032, New York, NY, USA aut Sauer Mark Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W168th Street, PH-16, 10032, New York, NY, USA aut Lobo Rogerio Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W168th Street, PH-16, 10032, New York, NY, USA aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/11(2011-11-01), 1067-1072 1058-0468 28:11<1067 2011 28 10815 https://doi.org/10.1007/s10815-011-9643-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9643-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jovanovic Vuk Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W168th Street, PH-16, 10032, New York, NY, USA aut NATIONALLICENCE 700 1- Kort Daniel Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W168th Street, PH-16, 10032, New York, NY, USA aut NATIONALLICENCE 700 1- Guarnaccia Michael Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W168th Street, PH-16, 10032, New York, NY, USA aut NATIONALLICENCE 700 1- Sauer Mark Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W168th Street, PH-16, 10032, New York, NY, USA aut NATIONALLICENCE 700 1- Lobo Rogerio Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 W168th Street, PH-16, 10032, New York, NY, USA aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/11(2011-11-01), 1067-1072 1058-0468 28:11<1067 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer