caa a22 4500 445818204 CHVBK 20180317145235.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10815-011-9635-4 doi (NATIONALLICENCE)springer-10.1007/s10815-011-9635-4 Brain-derived neurotrophic factor from follicular fluid is positively associated with rate of mature ooocytes collected and cleavage rate in intracytoplasmic sperm injection patients [Elektronische Daten] [Xue Wang, Zhengyi Sun, Jingran Zhen, Qi Yu] Purpose: The aim of the study was to evaluate the correlation between BDNF and oocyte maturation and to verify whether BDNF could predict in vitro fertilization (IVF) outcome. Methods: The follicle fluid (FF) for BDNF, E2 and P assay were obtained from 59 patients undergoing intracytoplasmic sperm injection (ICSI). The women were divided into two groups by pregnancy outcome and their clinical and lab data were compared. And the correlation of BDNF with E2, P, age, and IVF data were analyzed. Results: Positive correlation was observed between BDNF and E2 concentration in FF. BDNF was positively correlated with the rate of mature oocytes collected and cleavage rate. Conclusions: The BDNF in FF could not predict IVF outcome, but BDNF in FF might play an important role in the maturation of oocyte and development of oocyte into preimplantation embryo. Springer Science+Business Media, LLC, 2011 Brain-derived neurotrophic factor nationallicence Oocyte nationallicence Follicle fluid nationallicence Rate of mature oocytes collected nationallicence Cleavage rate nationallicence Wang Xue Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 100730, Beijing, China aut Sun Zhengyi Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 100730, Beijing, China aut Zhen Jingran Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 100730, Beijing, China aut Yu Qi Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 100730, Beijing, China aut Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/11(2011-11-01), 1053-1058 1058-0468 28:11<1053 2011 28 10815 https://doi.org/10.1007/s10815-011-9635-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10815-011-9635-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Xue Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 700 1- Sun Zhengyi Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 700 1- Zhen Jingran Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 700 1- Yu Qi Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 100730, Beijing, China aut NATIONALLICENCE 773 0- Journal of Assisted Reproduction and Genetics Springer US; http://www.springer-ny.com 28/11(2011-11-01), 1053-1058 1058-0468 28:11<1053 2011 28 10815 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer