caa a22 4500 445820845 CHVBK 20180317145243.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00239-011-9463-2 doi (NATIONALLICENCE)springer-10.1007/s00239-011-9463-2 Selection-Driven Divergence After Gene Duplication in Arabidopsis thaliana [Elektronische Daten] [Toni Gossmann, Karl Schmid] Gene duplications are one of the most important mechanisms for the origin of evolutionary novelties. Even though various models of the fate of duplicated genes have been established, current knowledge about the role of divergent selection after gene duplication is rather limited. In this study, we analyzed sequence divergence in response to neo- and subfunctionalization of segmentally duplicated genes in the genome of Arabidopsis thaliana. We compared the genomes of A. thaliana and the poplar Populus trichocarpa to identify orthologous pairs of genes and their corresponding inparalogs. Maximum-likelihood analyses of the nonsynonymous and synonymous substitution rate ratio $$ \left( {\omega = d_{\rm{N}} /d_{\rm{S}} } \right) $$ of pairs of A. thaliana inparalogs were used to detect differences in the evolutionary rates of protein coding sequences. We analyzed 1,924 A. thaliana paralogous pairs and our results indicate that around 6.9% show divergent ω values between the lineages for a fraction of sites. We observe an enrichment of regulatory sequences, a reduced level of co-expression and an increased number of substitutions that can be attributed to positive selection based on an McDonald-Kreitman type of analysis. Taken together, these results show that selection after duplication contributes substantially to gene novelties and hence functional divergence in plants. Springer Science+Business Media, LLC, 2011 Duplication nationallicence Natural selection nationallicence Paralogs nationallicence A. thaliana nationallicence Gossmann Toni Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK), 06466, Gatersleben, Germany aut Schmid Karl Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK), 06466, Gatersleben, Germany aut Journal of Molecular Evolution Springer-Verlag 73/3-4(2011-10-01), 153-165 0022-2844 73:3-4<153 2011 73 239 https://doi.org/10.1007/s00239-011-9463-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00239-011-9463-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gossmann Toni Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK), 06466, Gatersleben, Germany aut NATIONALLICENCE 700 1- Schmid Karl Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK), 06466, Gatersleben, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Evolution Springer-Verlag 73/3-4(2011-10-01), 153-165 0022-2844 73:3-4<153 2011 73 239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer