caa a22 4500 445821469 CHVBK 20180317145245.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00239-010-9425-0 doi (NATIONALLICENCE)springer-10.1007/s00239-010-9425-0 Role of Everlasting Triplet Expansions in Protein Evolution [Elektronische Daten] [Zohar Koren, Edward Trifonov] Analysis of occurrence of simple amino acid repeats in large ensemble of prokaryotic and eukaryotic sequences reveals that nearly all amino acids found in the repeats belong to those which have in their codon repertoires aggressively expanding triplets, all of three known pathologically expanding classes GCU (GCU, CUG, UGC, AGC, GCA, CAG), GCC (GCC, CCG, CGC, GGC, GCG, CGG), and AAG (AAG, AGA, GAA, CTT, TTC, TCT). This is observed especially clear in the first exons of proteins of higher eukaryotes. The data are interpreted as manifestation of everlasting triplet expansions, which, presumably, started from the very origin of the triplet code. The spontaneous expansions continued to occur all the way during evolution, leaving their footprints in the protein-coding sequences as still visible simple amino acid repeats, as preferred triplets encoding the repeats, and as preferred codons in the codon usage tables. Springer Science+Business Media, LLC, 2010 Codon usage nationallicence Evolutionary play-ground nationallicence Fast adaptation nationallicence First exons nationallicence Genome inflation nationallicence Homopeptides nationallicence Selfish DNA nationallicence Tandem repeats nationallicence Triplet code nationallicence Triplet expansion disorders nationallicence Koren Zohar Genome Diversity Center, Institute of Evolution, University of Haifa, 31905, Mount Carmel, Haifa, Israel aut Trifonov Edward Genome Diversity Center, Institute of Evolution, University of Haifa, 31905, Mount Carmel, Haifa, Israel aut Journal of Molecular Evolution Springer-Verlag 72/2(2011-02-01), 232-239 0022-2844 72:2<232 2011 72 239 https://doi.org/10.1007/s00239-010-9425-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00239-010-9425-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koren Zohar Genome Diversity Center, Institute of Evolution, University of Haifa, 31905, Mount Carmel, Haifa, Israel aut NATIONALLICENCE 700 1- Trifonov Edward Genome Diversity Center, Institute of Evolution, University of Haifa, 31905, Mount Carmel, Haifa, Israel aut NATIONALLICENCE 773 0- Journal of Molecular Evolution Springer-Verlag 72/2(2011-02-01), 232-239 0022-2844 72:2<232 2011 72 239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer