caa a22 4500 445821515 CHVBK 20180317145245.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00239-010-9423-2 doi (NATIONALLICENCE)springer-10.1007/s00239-010-9423-2 Amos William Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK aut Population-Specific Links Between Heterozygosity and the Rate Human Microsatellite Evolution [Elektronische Daten] [William Amos] Microsatellites form an abundant class of DNA sequences used widely as genetic markers. Surprisingly, the length of human microsatellites varies highly predictably with distance from Africa, apparently following the linear decline in variability that arose as we colonised the world. Such patterns have been used to argue that heterozygosity modulates the rate of microsatellite evolution. Here I test the ensuing prediction that variation in demographic history will cause individual populations predictably either to lead or to lag any given trend in length. I find that they do: larger populations with locally higher heterozygosity have microsatellites that are longer when a locus is expanding and shorter when a locus is contracting. These patterns remain even after controlling for the stepwise way in which heterozygosity and allele lengths decline across the world. This analysis provides support for a strongly discontinuous model for how human genetic variability is distributed and shows how individual populations differ in the average rate their microsatellites are evolving. Such patterns have the potential to provide a new window onto historical demography. Springer Science+Business Media, LLC, 2010 Microsatellite nationallicence Heterozygote instability nationallicence Human nationallicence Distance from Africa nationallicence Genetic variation nationallicence Journal of Molecular Evolution Springer-Verlag 72/2(2011-02-01), 215-221 0022-2844 72:2<215 2011 72 239 https://doi.org/10.1007/s00239-010-9423-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00239-010-9423-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Amos William Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK aut NATIONALLICENCE 773 0- Journal of Molecular Evolution Springer-Verlag 72/2(2011-02-01), 215-221 0022-2844 72:2<215 2011 72 239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer