caa a22 4500 445823259 CHVBK 20180317145251.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10616-011-9358-5 doi (NATIONALLICENCE)springer-10.1007/s10616-011-9358-5 In vitro cytotoxic potential of newly synthesized furo[3,2- c ]pyran-4-one derivatives in cultured human lymphocytes [Elektronische Daten] [Halil Eroğlu, İrfan Koca, İsmail Yıldırım] The in vitro cytotoxic potentials of Furo[3,2-c]pyran-4-one derivatives in human lymphocytes were investigated. Blood samples were obtained from six healthy donors, non-smoking volunteers, which were incubated and exposed to increasing concentrations (0.05, 0.1, 0.5, 1 and 2mg/mL) of Furo[3,2-c]pyran-4-one derivatives which are methyl 2-methoxy-7-(4-methylbenzoyl)-6-(4-methylphenyl)-4-oxo-4H-furo[3,2-c]pyran-3-carboxylate (1a) and methyl 2-methoxy-7-(4-methoxybenzoyl)-6-(4-methoxyphenyl)-4-oxo-4H-furo[3,2-c]pyran-3-carboxylate (1b). Compounds 1a and 1b induced micronucleus, mitotic and replication indexes in human lymphocytes (1 and 2mg/mL). The increases of micronucleus, mitotic and replication indexes show that compounds at high concentrations may become cytotoxic, genotoxic and carcinogenic. Springer Science+Business Media B.V., 2011 Cytotoxic nationallicence Furo[3,2- c ]pyran-4-one nationallicence Neo-tanshinlactone nationallicence Eroğlu Halil Department of Biology, Faculty of Science and Art, Bozok University, 66200, Yozgat, Turkey aut Koca İrfan Department of Chemistry, Faculty of Science and Art, Bozok University, 66200, Yozgat, Turkey aut Yıldırım İsmail Department of Chemistry, Faculty of Science, Erciyes University, 38039, Kayseri, Turkey aut Cytotechnology Springer Netherlands 63/4(2011-08-01), 407-413 0920-9069 63:4<407 2011 63 10616 https://doi.org/10.1007/s10616-011-9358-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10616-011-9358-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Eroğlu Halil Department of Biology, Faculty of Science and Art, Bozok University, 66200, Yozgat, Turkey aut NATIONALLICENCE 700 1- Koca İrfan Department of Chemistry, Faculty of Science and Art, Bozok University, 66200, Yozgat, Turkey aut NATIONALLICENCE 700 1- Yıldırım İsmail Department of Chemistry, Faculty of Science, Erciyes University, 38039, Kayseri, Turkey aut NATIONALLICENCE 773 0- Cytotechnology Springer Netherlands 63/4(2011-08-01), 407-413 0920-9069 63:4<407 2011 63 10616 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer