caa a22 4500 44582350X CHVBK 20180317145252.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10616-010-9326-5 doi (NATIONALLICENCE)springer-10.1007/s10616-010-9326-5 Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients: randomized, double-blind, placebo-controlled study [Elektronische Daten] [Hiroyuki Itoh, Masayuki Uchida, Toshihiro Sashihara, Zai-Si Ji, Ji Li, Qianjue Tang, Shuang Ni, Linyi Song, Shuichi Kaminogawa] In this study, we evaluated the efficacy of Lactobacillus gasseri OLL2809 on endometriosis by the randomized, double-blind and placebo-controlled clinical study, especially against pain, which is one of the causative factors to decrease the quality of life. Sixty-six patients clinically diagnosed with endometriosis were enrolled in this study, 62 of which have successfully completed the trial. The tablets containing 100mg of L. gasseri OLL2809 (active tablet, n=29) or placebo tablets (n=33) were ingested once a day for 12weeks. Visual analog scale (VAS) of pain intensity at the menstrual period and verbal rating scale (VRS) of dysmenorrhea were significantly improved by the ingestion of the active tablets as compared with placebo tablets. There was no significant change of blood examination and biochemical examination of blood in the enrolled patients. Above results show that the tablet containing L. gasseri OLL2809 is effective on endometriosis, especially against menstrual pain and dysmenorrhea. Moreover, it was found that the tablet has no adverse effects. Therefore, it was suggested that the tablet containing L. gaserri OLL2809 contributes to improve the quality of life in the patients with endometriosis. Springer Science+Business Media B.V., 2010 Lactobacillus gasseri OLL2809 nationallicence Endometriosis nationallicence Menstrual pain nationallicence Dysmenorrhea nationallicence VAS : Visual analog scale nationallicence VRS : Verbal rating scale nationallicence NK : Natural killer nationallicence IL : Interleukin nationallicence QOL : Quality of life nationallicence Itoh Hiroyuki Food Science Institute, Meiji Dairies Corporation, 540 Naruda, 250-0862, Odawara, Kanagawa, Japan aut Uchida Masayuki Food Science Institute, Meiji Dairies Corporation, 540 Naruda, 250-0862, Odawara, Kanagawa, Japan aut Sashihara Toshihiro Food Science Institute, Meiji Dairies Corporation, 540 Naruda, 250-0862, Odawara, Kanagawa, Japan aut Ji Zai-Si Food Science Institute, Meiji Dairies Corporation, 540 Naruda, 250-0862, Odawara, Kanagawa, Japan aut Li Ji Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, 200032, Shanghai, People's Republic of China aut Tang Qianjue Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, 200032, Shanghai, People's Republic of China aut Ni Shuang Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, 200032, Shanghai, People's Republic of China aut Song Linyi Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, 200032, Shanghai, People's Republic of China aut Kaminogawa Shuichi Department of Food Science and Technology, College of Bioresource Sciences, Nihon University, 1866 Kameino, 252-8510, Fujisawa, Kanagawa, Japan aut Cytotechnology Springer Netherlands 63/2(2011-03-01), 153-161 0920-9069 63:2<153 2011 63 10616 https://doi.org/10.1007/s10616-010-9326-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10616-010-9326-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Itoh Hiroyuki Food Science Institute, Meiji Dairies Corporation, 540 Naruda, 250-0862, Odawara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Uchida Masayuki Food Science Institute, Meiji Dairies Corporation, 540 Naruda, 250-0862, Odawara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Sashihara Toshihiro Food Science Institute, Meiji Dairies Corporation, 540 Naruda, 250-0862, Odawara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Ji Zai-Si Food Science Institute, Meiji Dairies Corporation, 540 Naruda, 250-0862, Odawara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Li Ji Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, 200032, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Tang Qianjue Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, 200032, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Ni Shuang Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, 200032, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Song Linyi Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, 200032, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Kaminogawa Shuichi Department of Food Science and Technology, College of Bioresource Sciences, Nihon University, 1866 Kameino, 252-8510, Fujisawa, Kanagawa, Japan aut NATIONALLICENCE 773 0- Cytotechnology Springer Netherlands 63/2(2011-03-01), 153-161 0920-9069 63:2<153 2011 63 10616 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer