caa a22 4500 445823518 CHVBK 20180317145252.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10616-011-9343-z doi (NATIONALLICENCE)springer-10.1007/s10616-011-9343-z Lactobacillus gasseri OLL2809 inhibits development of ectopic endometrial cell in peritoneal cavity via activation of NK cells in a murine endometriosis model [Elektronische Daten] [Hiroyuki Itoh, Toshihiro Sashihara, Akira Hosono, Shuichi Kaminogawa, Masayuki Uchida] We have previously reported that peritoneal administration of interleukin-12 (IL-12) suppresses development of ectopic endometriotic lesions via activation of natural killer (NK) cells in a mouse endometriosis model. Lactobacillus gasseri OLL2809 is one of a probiotic lactobacillus that has been selected on an ability to stimulate production of IL-12 from murine splenocytes. In this study, we examined whether the oral administration of heat-killed L. gasseri OLL2809 suppressed development of endometriosis. Administration of L. gasseri OLL2809 for 21 consecutive days resulted in reduction of the development of ectopic endometriotic lesions in an extent similar to IL-12. Although obvious effects of L. gasseri OLL2809 on the peritoneal cytokine levels, population of peritoneal cells as well as cytotoxicity of splenic NK cells, gene expression analysis of the peritoneal cells revealed enhancement in the transcription of IL-2 and natural killer cell triggering receptor 1 genes. Therefore, it was suggested that L. gasseri OLL2809 suppressed development of endometriosis via activation of NK cells. Springer Science+Business Media B.V., 2011 Endometriosis nationallicence IL-12 nationallicence Lactobacillus gasseri nationallicence Natural killer cell nationallicence IL : Interleukin nationallicence IFN : Interferon nationallicence NK : Natural killer nationallicence Th : Helper T cells nationallicence Itoh Hiroyuki Food Science Institute, Division of Research and Development, Meiji Dairies Corporation, 540 Naruda, Odawara, 250-0862, Kanagawa, Japan aut Sashihara Toshihiro Food Science Institute, Division of Research and Development, Meiji Dairies Corporation, 540 Naruda, Odawara, 250-0862, Kanagawa, Japan aut Hosono Akira Department of Food Science and Technology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, 252-8510, Kanagawa, Japan aut Kaminogawa Shuichi Department of Food Science and Technology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, 252-8510, Kanagawa, Japan aut Uchida Masayuki Food Science Institute, Division of Research and Development, Meiji Dairies Corporation, 540 Naruda, Odawara, 250-0862, Kanagawa, Japan aut Cytotechnology Springer Netherlands 63/2(2011-03-01), 205-210 0920-9069 63:2<205 2011 63 10616 https://doi.org/10.1007/s10616-011-9343-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10616-011-9343-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Itoh Hiroyuki Food Science Institute, Division of Research and Development, Meiji Dairies Corporation, 540 Naruda, Odawara, 250-0862, Kanagawa, Japan aut NATIONALLICENCE 700 1- Sashihara Toshihiro Food Science Institute, Division of Research and Development, Meiji Dairies Corporation, 540 Naruda, Odawara, 250-0862, Kanagawa, Japan aut NATIONALLICENCE 700 1- Hosono Akira Department of Food Science and Technology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, 252-8510, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kaminogawa Shuichi Department of Food Science and Technology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, 252-8510, Kanagawa, Japan aut NATIONALLICENCE 700 1- Uchida Masayuki Food Science Institute, Division of Research and Development, Meiji Dairies Corporation, 540 Naruda, Odawara, 250-0862, Kanagawa, Japan aut NATIONALLICENCE 773 0- Cytotechnology Springer Netherlands 63/2(2011-03-01), 205-210 0920-9069 63:2<205 2011 63 10616 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer