caa a22 4500 445823607 CHVBK 20180317145252.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00246-010-9819-1 doi (NATIONALLICENCE)springer-10.1007/s00246-010-9819-1 Use of a Cardioselective Beta-Blocker for Pediatric Patients With Prolonged QT Syndrome [Elektronische Daten] [Jose Moltedo, Jeffrey Kim, Richard Friedman, Naomi Kertesz, Bryan Cannon] The data on the efficacy of atenolol for long-QT syndrome (LQTS) are controversial. This study aimed to evaluate the efficacy of atenolol for pediatric patients with LQTS. A retrospective observational study investigating all patients who had LQTS treated with atenolol at two institutions was performed. The study identified 57 patients (23 boys and 34 girls) with a mean QT corrected for heart rate (QTc) of 521±54 ms. The mean age of these patients at diagnosis was 9 ± 6 years. Their clinical manifestations included no symptoms (n=33, 58%), ventricular tachycardia (n=10, 18%), syncope (n=6, 10%), resuscitated sudden cardiac death (n=4, 7%), atrioventricular block (n=2, 4%), and bradycardia or presyncope (n=2, 3%). Of the 57 patients, 13 (22%) had a family history of sudden death. The follow-up period was 5.4±4.5 years. Atenolol at a mean dose of 1.4±0.5 mg/kg/day was administered twice a day for all the patients. The mean maximum heart rate was 132±27 bpm on Holter monitors and 155±16bpm on exercise treadmill tests, with medication doses titrated up to achieve a maximum heart rate lower than 150 bpm on both tests. During the follow-up period, one patient died (noncompliant with atenolol at the time of death), and the remaining patients had no sudden cardiac death events. Four patients (8%) had recurrent ventricular arrhythmias, three of whom received an implantable cardioverter defibrillator (all symptomatic at the time of diagnosis). For three patients (6%), it was necessary to rotate to a different beta-blocker because of side effects or inadequate heart rate control. Atenolol administered twice daily constitutes a valid and effective alternative for the treatment of pediatric patients with LQTS. Springer Science+Business Media, LLC, 2010 Atenolol nationallicence Long-QT syndrome nationallicence Pediatrics nationallicence Therapy nationallicence Moltedo Jose Section of Pediatric Cardiology, Fundacion contra las enfermedades Neurologicas de la Infancia, Buenos Aires, Argentina aut Kim Jeffrey Section of Cardiology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA aut Friedman Richard Section of Cardiology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA aut Kertesz Naomi Section of Cardiology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA aut Cannon Bryan Section of Cardiology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA aut Pediatric Cardiology Springer-Verlag 32/1(2011-01-01), 63-66 0172-0643 32:1<63 2011 32 246 https://doi.org/10.1007/s00246-010-9819-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9819-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moltedo Jose Section of Pediatric Cardiology, Fundacion contra las enfermedades Neurologicas de la Infancia, Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Kim Jeffrey Section of Cardiology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA aut NATIONALLICENCE 700 1- Friedman Richard Section of Cardiology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA aut NATIONALLICENCE 700 1- Kertesz Naomi Section of Cardiology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA aut NATIONALLICENCE 700 1- Cannon Bryan Section of Cardiology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/1(2011-01-01), 63-66 0172-0643 32:1<63 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer