caa a22 4500 445823712 CHVBK 20180317145252.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00246-010-9813-7 doi (NATIONALLICENCE)springer-10.1007/s00246-010-9813-7 Brain Maturity and Brain Injury in Newborns With Cyanotic Congenital Heart Disease [Elektronische Daten] [Soad Shedeed, Eman Elfaytouri] Patients with congenital heart disease (CHD) are at high risk for adverse neurodevelopmental outcomes. The aim of this work was to assess brain maturity and brain injury in newborns with cyanotic CHD using proton magnetic resonance spectroscopy (MRS). The study included 38 newborns with cyanotic CHD (study group) and 20 healthy full-term newborns (control group) matched together regarding gestational age and sex. Three-dimensional MRS showed that the mean ratio of N-acetylaspartate to choline (Ch) was significantly lower in newborns with cyanotic CHD (0.55±0.08) compared with controls (0.67±0.11) (p<0.001). However, the mean ratio of lactate to Ch metabolite was significantly higher in the studied cases (0.14±0.04) compared with controls (0.09±0.04) (p<0.001). The mean value for average diffusivity was 1.41±0.06 in newborns with cyanotic CHD compared with 1.27±0.07 in control newborns (p<0.001), and the mean value for white-matter fractional anisotropy was 0.19±0.03 in cyanotic newborns and 0.25±0.08 in controls (p<0.001). Newborns with cyanotic CHD are at increased risk of cerebral white matter injury as well as poor brain maturity. MRS provides a surrogate marker for early detection of such brain abnormalities. Springer Science+Business Media, LLC, 2010 Cyanotic congenital heart disease nationallicence N -acetylaspartate nationallicence Newborn nationallicence MRS nationallicence Shedeed Soad Pediatrics Department, Zagazig University, Zagazig, Egypt aut Elfaytouri Eman Radiology Department, Gharian Teaching Hospital, Gharian, Libya aut Pediatric Cardiology Springer-Verlag 32/1(2011-01-01), 47-54 0172-0643 32:1<47 2011 32 246 https://doi.org/10.1007/s00246-010-9813-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-010-9813-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shedeed Soad Pediatrics Department, Zagazig University, Zagazig, Egypt aut NATIONALLICENCE 700 1- Elfaytouri Eman Radiology Department, Gharian Teaching Hospital, Gharian, Libya aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/1(2011-01-01), 47-54 0172-0643 32:1<47 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer