caa a22 4500 445824042 CHVBK 20180317145253.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00246-011-9950-7 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9950-7 Connective Tissue Disease Presenting With Signs and Symptoms of Pulmonary Hypertension in Children [Elektronische Daten] [Shinichi Takatsuki, Jennifer Soep, Michelle Calderbank, David Ivy] Our case series describes three children who were initially diagnosed as having severe pulmonary arterial hypertension (PAH) and subsequently found to be positive for specific autoantibodies suggestive of an underlying autoimmune process. The signs and symptoms of PAH are subtle and may be part of the initial presentation of childhood connective tissue disease (CTD). Evaluation for connective tissue disease in the newly diagnosed pulmonary hypertension (PH) patient is important because early diagnosis of PH as well as CTD is crucial in the successful management of these complex patients. Ongoing monitoring for CTD in patients with severe PAH is warranted. Springer Science+Business Media, LLC, 2011 Pulmonary arterial hypertension nationallicence Autoantibody nationallicence Pulmonary vasodilator therapies nationallicence Antinuclear antibody nationallicence Connective tissue disease nationallicence Children nationallicence Takatsuki Shinichi Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine, 3123 East 16th Avenue, B100, 80045, Aurora, CO, USA aut Soep Jennifer Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine, 3123 East 16th Avenue, B100, 80045, Aurora, CO, USA aut Calderbank Michelle Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine, 3123 East 16th Avenue, B100, 80045, Aurora, CO, USA aut Ivy David Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine, 3123 East 16th Avenue, B100, 80045, Aurora, CO, USA aut Pediatric Cardiology Springer-Verlag 32/6(2011-08-01), 828-833 0172-0643 32:6<828 2011 32 246 https://doi.org/10.1007/s00246-011-9950-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9950-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takatsuki Shinichi Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine, 3123 East 16th Avenue, B100, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Soep Jennifer Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine, 3123 East 16th Avenue, B100, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Calderbank Michelle Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine, 3123 East 16th Avenue, B100, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Ivy David Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine, 3123 East 16th Avenue, B100, 80045, Aurora, CO, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/6(2011-08-01), 828-833 0172-0643 32:6<828 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer