caa a22 4500 445824069 CHVBK 20180317145253.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00246-011-9969-9 doi (NATIONALLICENCE)springer-10.1007/s00246-011-9969-9 Cardiac Functions in Children With Growth Hormone Deficiency Before and During Growth Hormone-Replacement Therapy [Elektronische Daten] [Osman Ozdemir, Ayhan Abaci, Samil Hizli, Cem Razi, Ahmet Akelma, Mesut Kocak, Fatih Kislal] Childhood growth hormone deficiency (GHD) decreases left-ventricular (LV) mass, but impairment of cardiac function has never been documented. The objective of this study was to assess the cardiac effects of GHD and recombinant human growth hormone (rhGH) treatment using conventional echocardiography and tissue Doppler imaging. Complete two-dimensional, M-mode, pulse-wave Doppler echocardiography and pulse-wave tissue Doppler imaging were performed in 12 children (6 male and 6 female patients) with GHD at baseline and at 5.86±1.61months after rhGH therapy. Recombinant human growth hormone treatment was associated with a significant increase in LV mass index (63.8±27.1 to 79.3±30.3g/m2; P<0.01) and LV internal dimensions (21.4±2.63 to 24.0±4.13mm in systole [P=0.03] and 36.5±3.90 to 39.5±4.94mm in diastole [P<0.01]). There were statistical differences of parameters, such as deceleration time of early peak velocity of mitral, isovolumic relaxation time, and myocardial performance index (103±15.4 to 139±21.2ms [P<0.01], 55.5±9.24 to 69.2±3.74ms [P<0.01], and 37.8±4.46 to 44.9±5.44% [P<0.01], respectively). Before and during rhGH therapy, there were no significant differences in fractional shortening of the left ventricle, peak mitral, and tricuspid wave velocities with ratios determined using conventional echocardiography and tissue Doppler imaging. In children, GHD affects heart morphology by inducing a decrease in cardiac size, but it does not modify cardiac function. Recombinant human growth hormone treatment increases cardiac mass, deceleration time of early peak velocity of the mitral valve, isovolumic relaxation time, and myocardial performance index, but it does not make a difference in other parameters of conventional echocardiography and tissue Doppler imaging. Springer Science+Business Media, LLC, 2011 Cardiac function nationallicence Growth hormone nationallicence Tissue Doppler imaging nationallicence Ozdemir Osman Department of Paediatric Cardiology, Kecioren Training and Research Hospital, Ankara, Turkey aut Abaci Ayhan Department of Paediatric Endocrinology, Kecioren Training and Research Hospital, Ankara, Turkey aut Hizli Samil Department of Paediatric Gastroenterology, Hepatology, and Nutrition, Kecioren Training and Research Hospital, Ankara, Turkey aut Razi Cem Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey aut Akelma Ahmet Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey aut Kocak Mesut Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey aut Kislal Fatih Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey aut Pediatric Cardiology Springer-Verlag 32/6(2011-08-01), 766-771 0172-0643 32:6<766 2011 32 246 https://doi.org/10.1007/s00246-011-9969-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-9969-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ozdemir Osman Department of Paediatric Cardiology, Kecioren Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Abaci Ayhan Department of Paediatric Endocrinology, Kecioren Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Hizli Samil Department of Paediatric Gastroenterology, Hepatology, and Nutrition, Kecioren Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Razi Cem Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Akelma Ahmet Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Kocak Mesut Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Kislal Fatih Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/6(2011-08-01), 766-771 0172-0643 32:6<766 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer