caa a22 4500 445824174 CHVBK 20180317145254.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00246-011-0032-7 doi (NATIONALLICENCE)springer-10.1007/s00246-011-0032-7 Benign Outcome of Pulmonary Hypertension in Neonates With a Restrictive Patent Foramen Ovale Versus Result for Neonates With an Unrestrictive Patent Foramen Ovale [Elektronische Daten] [Umang Gupta, Ra-id Abdulla, John Bokowski] Premature closure or restriction of foramen ovale (FO) is a rare but known entity. FO diameter <2mm and Doppler velocity >120cm/s, diameter <3mm with Doppler velocity measured gradient >5mmHg have all being used by various authors to describe this entity. Some neonates with restrictive FO have been noted to have severe pulmonary hypertension with no clinical signs or symptoms and with spontaneous resolution without any intervention. Seven consecutive neonates were indentified in the database between 01/01/2003 and 06/30/2010 with diagnosis of restrictive PFO (diameter <2mm) with structurally normal heart and their initial and follow-up echocardiogram as well as hospital medical records were reviewed. As a control, seven neonates with diagnosis of pulmonary hypertension and respiratory distress syndrome or meconium aspiration syndrome were randomly selected. Eighty-six percent of the patients in the control group were symptomatic and required treatment as compared to 14% in the restrictive FO group (p=0.03). Further, the fall in the peak instantaneous pulmonary artery pressure on follow-up echocardiogram was greater in the restrictive FO group compared with the non-restrictive group (p=0.03). Patients with pulmonary hypertension and a restrictive FO with no other associated congenital heart disease and/or lung pathology behave differently when compared to neonates with non-restrictive FO and pulmonary hypertension with associated lung disease. They seldom manifest symptoms requiring intervention and tend to show a faster drop in their pulmonary artery pressure toward the normal. Springer Science+Business Media, LLC, 2011 Neonates nationallicence Pulmonary hypertension nationallicence Restrictive foramen ovale nationallicence Gupta Umang Department of Pediatric Cardiology, Rush University Medical Center, Chicago, IL, USA aut Abdulla Ra-id Department of Pediatric Cardiology, Rush University Medical Center, Chicago, IL, USA aut Bokowski John Department of Pediatric Cardiology, Rush University Medical Center, Chicago, IL, USA aut Pediatric Cardiology Springer-Verlag 32/7(2011-10-01), 972-976 0172-0643 32:7<972 2011 32 246 https://doi.org/10.1007/s00246-011-0032-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-0032-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gupta Umang Department of Pediatric Cardiology, Rush University Medical Center, Chicago, IL, USA aut NATIONALLICENCE 700 1- Abdulla Ra-id Department of Pediatric Cardiology, Rush University Medical Center, Chicago, IL, USA aut NATIONALLICENCE 700 1- Bokowski John Department of Pediatric Cardiology, Rush University Medical Center, Chicago, IL, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/7(2011-10-01), 972-976 0172-0643 32:7<972 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer