caa a22 4500 445824379 CHVBK 20180317145254.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00246-011-0013-x doi (NATIONALLICENCE)springer-10.1007/s00246-011-0013-x Pulmonary Limitation to Exercise After Repair of D-Transposition of the Great Vessels: Atrial Baffle Versus Arterial Switch [Elektronische Daten] [Lauren Sterrett, Eric Ebenroth, Gregory Montgomery, Marcus Schamberger, Roger Hurwitz] This study evaluated resting pulmonary function and its impact on exercise capacity after atrial baffle (BAFFLE) and arterial switch (SWITCH) repair of D-transposition of the great vessels (DTGV). Previously decreased exercise capacity in DTGV patients has been primarily attributed to cardiovascular limitations, whereas pulmonary limitations have largely been overlooked. Resting flow volume loops were compared for BAFFLE (n=34) and SWITCH (n=32) patients. Peak exercise variables were compared for BAFFLE (n=30) and SWITCH (n=25). Lung disease (restrictive and/or obstructive) was present in 53% of DTGV patients (BAFFLE 62% and SWITCH 44%; p=0.14). BAFFLE patients had a normal breathing reserve, whereas that of SWITCH patients was decreased (27.3±28.3 vs. 13.0±19.2; p=0.04). BAFFLE patients attained a lower percent of predicted peak oxygen pulse (82.7±20.5% vs. 94.7±19.3%; p=0.04) and peak oxygen consumption (VO2peak) (26.6±6.7ml/kg/min vs. 37.3±8.5ml/kg/min; p<0.01) than SWITCH patients. Patients after surgical repair for DTGV have an underappreciated occurrence of lung disease, even post-SWITCH. SWITCH patients have diminished breathing reserves, suggesting a pulmonary limitation to VO2peak. BAFFLE patients have lower VO2peaks, greater breathing reserves, and lower oxygen pulses than SWITCH patients, suggesting a cardiac limitation to peak aerobic capacity with probable secondary pulmonary limitations. Treating underlying lung disease in symptomatic patients after repair of DTGV may improve functional status. Springer Science+Business Media, LLC, 2011 Pulmonary function nationallicence D-transposition of the great vessels nationallicence Exercise nationallicence Sterrett Lauren Department of Pediatric Cardiology, Riley Hospital for Children at Indiana University Center, 702 Barnhill Drive, RR 127, 46202-5225, Indianapolis, IN, USA aut Ebenroth Eric Department of Pediatric Cardiology, Riley Hospital for Children at Indiana University Center, 702 Barnhill Drive, RR 127, 46202-5225, Indianapolis, IN, USA aut Montgomery Gregory Department of Pediatric Pulmonology, Riley Hospital for Children at Indiana University Center, Indianapolis, IN, USA aut Schamberger Marcus Department of Pediatric Cardiology, Riley Hospital for Children at Indiana University Center, 702 Barnhill Drive, RR 127, 46202-5225, Indianapolis, IN, USA aut Hurwitz Roger Department of Pediatric Cardiology, Riley Hospital for Children at Indiana University Center, 702 Barnhill Drive, RR 127, 46202-5225, Indianapolis, IN, USA aut Pediatric Cardiology Springer-Verlag 32/7(2011-10-01), 910-916 0172-0643 32:7<910 2011 32 246 https://doi.org/10.1007/s00246-011-0013-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-0013-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sterrett Lauren Department of Pediatric Cardiology, Riley Hospital for Children at Indiana University Center, 702 Barnhill Drive, RR 127, 46202-5225, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Ebenroth Eric Department of Pediatric Cardiology, Riley Hospital for Children at Indiana University Center, 702 Barnhill Drive, RR 127, 46202-5225, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Montgomery Gregory Department of Pediatric Pulmonology, Riley Hospital for Children at Indiana University Center, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Schamberger Marcus Department of Pediatric Cardiology, Riley Hospital for Children at Indiana University Center, 702 Barnhill Drive, RR 127, 46202-5225, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Hurwitz Roger Department of Pediatric Cardiology, Riley Hospital for Children at Indiana University Center, 702 Barnhill Drive, RR 127, 46202-5225, Indianapolis, IN, USA aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/7(2011-10-01), 910-916 0172-0643 32:7<910 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer