caa a22 4500 445824387 CHVBK 20180317145254.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00246-011-0012-y doi (NATIONALLICENCE)springer-10.1007/s00246-011-0012-y Influence of Chromosome 22q11.2 Microdeletion on Postoperative Calcium Level After Cardiac-Correction Surgery [Elektronische Daten] [Li Shen, Haitao Gu, Dongjing Wang, Chi Yang, Zhengfeng Xu, Hua Jing, Yongzhong Jiang, Yibing Ding, Huacheng Hou, Zhijuan Ge, Shilin Chen, Xuming Mo, Long Yi] One of the most common constitutional chromosomal abnormalities, 22q11.2 microdeletion (del22q11.2) syndrome has diverse medical complications, such as congenital heart defect, hypocalcaemia, and immune deficiency, which require coordinated multidisciplinary care. Until now, the natural history of hypocalcaemia in chromosome del22q11.2 syndrome had been only partly documented, but there has been limited recognition of the importance of calcium status during the postoperative period when altered calcium status may be associated with serious complications. The goals of our study were (1) to delineate the clinical characteristics of serum calcium in patients with del22q11.2 during the postoperative period and (2) to make recommendations for the investigation and management of del22q11.2 patients after cardiac correction. This study included 22 children diagnosed with del22q11.2 syndrome and 110 children without del22q11.2 syndrome from Nanjing Children's Hospital. Clinical examinations and blood ionized calcium testing were reviewed retrospectively. A comparative study of postoperative calcium levels and complications of del22q11.2 patients with nondeletion patients was performed. Association between postoperative hypocalcaemia and adverse incidents after cardiac correction was also examined. Postoperative hypocalcaemia was observed among 86.4% of del22q11.2 patients and among only 47.3% of nondeletion subjects. The difference was statistically significant (P=0.0017). Patients with del22q11.2 syndrome also had a much sharper decrease in serum calcium levels during the first 6h after surgery than nondeletion patients. Postoperative clinical analysis showed that del22q11.2 patients with hypocalcaemia experience more postoperative complications (18 of 19) and greater mortality (5 of 19) after cardiac correction than del22q11.2 patients without normal calcium levels and nondeletion patients. Del22q11.2 children have high susceptibility of hypocalcaemia during the postoperative period, and this low calcium status after cardiac correction may be associated with significant risk of postoperative complications and mortality in patients with del22q11.2. Springer Science+Business Media, LLC, 2011 Chromosome 22q11.2 microdeletion nationallicence Hypocalcaemia nationallicence Cardiac surgery nationallicence Congenital heart defects nationallicence CHD : Congenital heart defect nationallicence PTH : Parathyroid hormone nationallicence CFMSA : Competitive fluorescent multiplex STRP assay nationallicence TOF : Tetralogy of Fallot nationallicence VSD : Ventricular septal defect nationallicence FISH : Fluorescent in situ hybridization nationallicence SPSS : Statistical Package for the Social Sciences nationallicence CPB : Cardiopulmonary bypass nationallicence Shen Li Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut Gu Haitao Department of Cardiothoracic Surgery, Nanjing Children's Hospital, Nanjing Medical University, 210008, Nanjing, People's Republic of China aut Wang Dongjing Department of Cardiothoracic Surgery, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, People's Republic of China aut Yang Chi Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut Xu Zhengfeng Center of Prenatal Diagnosis, Nanjing Maternity and Child Health Hospital, Nanjing Medical University, Nanjing, People's Republic of China aut Jing Hua Department of Cardiothoracic Surgery, Jinling Hospital, Clinical Medicine School, Nanjing University, Nanjing, People's Republic of China aut Jiang Yongzhong Department of Cardiothoracic Surgery, Nanjing Children's Hospital, Nanjing Medical University, 210008, Nanjing, People's Republic of China aut Ding Yibing Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut Hou Huacheng Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut Ge Zhijuan Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut Chen Shilin Department of Cardiothoracic Surgery, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, People's Republic of China aut Mo Xuming Department of Cardiothoracic Surgery, Nanjing Children's Hospital, Nanjing Medical University, 210008, Nanjing, People's Republic of China aut Yi Long Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut Pediatric Cardiology Springer-Verlag 32/7(2011-10-01), 904-909 0172-0643 32:7<904 2011 32 246 https://doi.org/10.1007/s00246-011-0012-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-0012-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shen Li Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Gu Haitao Department of Cardiothoracic Surgery, Nanjing Children's Hospital, Nanjing Medical University, 210008, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Wang Dongjing Department of Cardiothoracic Surgery, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Yang Chi Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Xu Zhengfeng Center of Prenatal Diagnosis, Nanjing Maternity and Child Health Hospital, Nanjing Medical University, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Jing Hua Department of Cardiothoracic Surgery, Jinling Hospital, Clinical Medicine School, Nanjing University, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Jiang Yongzhong Department of Cardiothoracic Surgery, Nanjing Children's Hospital, Nanjing Medical University, 210008, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Ding Yibing Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Hou Huacheng Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Ge Zhijuan Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Chen Shilin Department of Cardiothoracic Surgery, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Mo Xuming Department of Cardiothoracic Surgery, Nanjing Children's Hospital, Nanjing Medical University, 210008, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Yi Long Department of Pathology, Nanjing University Medical School, 210093, Nanjing, People's Republic of China aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/7(2011-10-01), 904-909 0172-0643 32:7<904 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence 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