caa a22 4500 445824506 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00246-011-0018-5 doi (NATIONALLICENCE)springer-10.1007/s00246-011-0018-5 Protective Effect of Propofol and Its Relation to Postoperation Recovery in Children Undergoing Cardiac Surgery with Cardiopulmonary Bypass [Elektronische Daten] [Wen-fang Xia, Yu Liu, Qing-shan Zhou, Qi-zhu Tang, Han-dong Zou] The aim of this study was to investigate the effect of propofol and its relation to postoperation recovery in children undergoing cardiac surgery with cardiopulmonary bypass (CPB). Twenty ASA class I-II children with congenital heart disease undergoing cardiac surgery were randomly allocated to a propofol group (n=10) or a control group (n=10). Blood samples were collected at five time points: before operation (T 0), before the start of CPB (T 1), 25min after the aorta was cross-clamped (T 2), 30min after release of the aortic cross-clamp (T 3), and 2h after the cessation of CPB (T 4). The myocardial samples were collected at the time of incubation into the right atrium before CPB and at 30min after reperfusion. After CPB, propofol significantly suppressed the increase of the serum lactate dehydrogenase (LDH), creatine phosphokinase (CK), and interleukin-6 (IL-6) levels and the decrease of the serum superoxide dismutase (SOD) level. In addition, propofol inhibited the increase of myocardial nuclear factor-κB (NF-κB) expression and inflammatory cells infiltration after CPB. Furthermore, propofol significantly shortened the tracheal extubation time. In conclusion, propofol exerts a protective effect and improves postoperation recovery through its antioxidant and anti-inflammatory actions in children undergoing cardiac surgery with CPB. Springer Science+Business Media, LLC, 2011 Propofol nationallicence Cardiopulmonary bypass nationallicence Oxidative stress nationallicence Inflammation nationallicence Children nationallicence Xia Wen-fang Departments of Critic Care Medicine and Cardiology, Renmin Hospital of Wuhan University, 430060, Wuhan, People's Republic of China aut Liu Yu Department of Cardiology, Renmin Hospital of Wuhan University, 430060, Wuhan, People's Republic of China aut Zhou Qing-shan Department of Critic Care Medicine, Renmin Hospital of Wuhan University, 430060, Wuhan, People's Republic of China aut Tang Qi-zhu Department of Cardiology, Renmin Hospital of Wuhan University, 430060, Wuhan, People's Republic of China aut Zou Han-dong Department of Critic Care Medicine, Renmin Hospital of Wuhan University, 430060, Wuhan, People's Republic of China aut Pediatric Cardiology Springer-Verlag 32/7(2011-10-01), 940-946 0172-0643 32:7<940 2011 32 246 https://doi.org/10.1007/s00246-011-0018-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-0018-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xia Wen-fang Departments of Critic Care Medicine and Cardiology, Renmin Hospital of Wuhan University, 430060, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Liu Yu Department of Cardiology, Renmin Hospital of Wuhan University, 430060, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Zhou Qing-shan Department of Critic Care Medicine, Renmin Hospital of Wuhan University, 430060, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Tang Qi-zhu Department of Cardiology, Renmin Hospital of Wuhan University, 430060, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Zou Han-dong Department of Critic Care Medicine, Renmin Hospital of Wuhan University, 430060, Wuhan, People's Republic of China aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/7(2011-10-01), 940-946 0172-0643 32:7<940 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer