caa a22 4500 445824565 CHVBK 20180317145255.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00246-011-0014-9 doi (NATIONALLICENCE)springer-10.1007/s00246-011-0014-9 Significance of Circulating Hepatocyte Growth Factor in Protein-Losing Enteropathy After Fontan Operation [Elektronische Daten] [Gi Kim, Bo Kwon, Eun Bae, Chung Noh, Jung Choi] The purpose of this study was to measure serum hepatocyte growth factor (HGF) and elucidate the relationship between HGF and protein-losing enteropathy (PLE) after Fontan operation (FO). Ten patients with PLE (mean age 15.7±8.7years) who underwent FO were enrolled. Control group 1 comprised 20 patients without PLE after FO, and control group 2 comprised 10 patients with nephrotic syndrome (NS). Serum HGF, vascular endothelial growth factor, albumin, and random stool alpha-1 antitrypsin concentration were measured. Transthoracic echocardiography was completed. Serum HGF level was significantly greater in the PLE patients (0.61±0.27ng/ml) after FO than in the two control groups (0.41±0.12ng/ml [P=0.024] for the Fontan group without PLE and 0.26±0.12ng/ml [P=0.002] for the patients with NS). Serum albumin of patients with PLE (2.82±0.96g/dl) showed significantly lower levels compared with those of patients without PLE after FO (4.30±0.37g/dl, P<0.001) but significantly greater levels compared with patients with NS (1.91±0.33g/dl, P=0.019). Patients with greater serum HGF levels showed significant correlation with lower serum albumin level (P=0.006, r=−0.495). Because serum HGF levels were significantly greater in patients with PLE after FO, HGF may play a role in the development of PLE after FO. Springer Science+Business Media, LLC, 2011 Fontan procedure nationallicence Protein-losing enteropathy nationallicence Hepatocyte growth factor nationallicence Albumin nationallicence Alpha-1 antitrypsin nationallicence Kim Gi Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea aut Kwon Bo Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea aut Bae Eun Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea aut Noh Chung Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea aut Choi Jung Department of Pediatrics, Bundang Hospital, Seoul National University, Kyeonggi-do, South Korea aut Pediatric Cardiology Springer-Verlag 32/7(2011-10-01), 917-923 0172-0643 32:7<917 2011 32 246 https://doi.org/10.1007/s00246-011-0014-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00246-011-0014-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Gi Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea aut NATIONALLICENCE 700 1- Kwon Bo Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea aut NATIONALLICENCE 700 1- Bae Eun Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea aut NATIONALLICENCE 700 1- Noh Chung Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea aut NATIONALLICENCE 700 1- Choi Jung Department of Pediatrics, Bundang Hospital, Seoul National University, Kyeonggi-do, South Korea aut NATIONALLICENCE 773 0- Pediatric Cardiology Springer-Verlag 32/7(2011-10-01), 917-923 0172-0643 32:7<917 2011 32 246 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer